Ferritin light chain
Encyclopedia
Ferritin light chain is a protein
that in humans is encoded by the FTL gene
.
It is abnormally expressed in fetuses of both IVF and ICSI
, which may contribute to the increase risk of birth defects in these ART
.
Mutations of the FTL gene cause the rare adult-onset basal ganglia disease
also known as neuroferritinopathy (OMIM 606159).
with FTH1
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the FTL gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
It is abnormally expressed in fetuses of both IVF and ICSI
Intracytoplasmic sperm injection
Intracytoplasmic sperm injection is an in vitro fertilization procedure in which a single sperm is injected directly into an egg.-Indications:...
, which may contribute to the increase risk of birth defects in these ART
Assisted reproductive technology
Assisted reproductive technology is a general term referring to methods used to achieve pregnancy by artificial or partially artificial means. It is reproductive technology used primarily in infertility treatments. Some forms of ART are also used in fertile couples for genetic reasons...
.
Mutations of the FTL gene cause the rare adult-onset basal ganglia disease
Basal ganglia disease
Basal ganglia disease refers to a group of physical dysfunctions that occur when the group of nuclei in the brain known as the basal ganglia fail to properly suppress unwanted movements or to properly prime upper motor neuron circuits to initiate motor function. Research indicates that increased...
also known as neuroferritinopathy (OMIM 606159).
Interactions
Ferritin light chain has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with FTH1
FTH1
Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene.- Function :This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains...
.