Flap structure-specific endonuclease 1

Flap endonuclease 1 is an enzyme

Enzyme

Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

that in humans is encoded by the FEN1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

Interactions

Flap structure-specific endonuclease 1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

with Cyclin-dependent kinase 2

Cyclin-dependent kinase 2

Cyclin-dependent kinase 2 also known as cell division protein kinase 2 is an enzyme that in humans is encoded by the CDK2 gene.-Function:...

, EP300

EP300

E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...

, Werner syndrome ATP-dependent helicase, Heterogeneous nuclear ribonucleoprotein A1, Cyclin A2

Cyclin A2

Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene.-Interactions:Cyclin A2 has been shown to interact with ITGB3BP, Retinoblastoma-like protein 1, E2F1, CDC6, SKP2 and Flap structure-specific endonuclease 1.-References:...

, PCNA

PCNA

Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome...

, Bloom syndrome protein

Bloom syndrome protein

Bloom syndrome protein is a protein that in humans is encoded by the BLM gene and is expressed in Bloom syndrome.The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities...

and APEX1

APEX1

DNA- lyase is an enzyme that in humans is encoded by the APEX1 gene.-Interactions:APEX1 has been shown to interact with MUTYH, Flap structure-specific endonuclease 1 and XRCC1.-Further reading:...