Fleck corneal dystrophy
Encyclopedia
Fleck corneal dystrophy (FCD; also Francois-Neetens speckled corneal dystrophy) is a rare form of human corneal dystrophy
. It is caused by mutations in PIP5K3 gene. Small opacities, some of which resemble "flecks", are scattered in the stroma of the patients. Other opacities look more like snowflakes or clouds. The disease is non-progressive and in most cases asymptomatic, with mild photophobia reported by some patients. In a single case report, a corneal transplantation was performed for concurrent keratoconus
, and at 10 years follow-up there was still no evidence of the inclusions in the stroma.
Corneal dystrophy (human)
Human corneal dystrophy is a group of disorders, characterised by a noninflammatory, inherited, bilateral opacity of the transparent front part of the human eye called the cornea...
. It is caused by mutations in PIP5K3 gene. Small opacities, some of which resemble "flecks", are scattered in the stroma of the patients. Other opacities look more like snowflakes or clouds. The disease is non-progressive and in most cases asymptomatic, with mild photophobia reported by some patients. In a single case report, a corneal transplantation was performed for concurrent keratoconus
Keratoconus
Keratoconus , is a degenerative disorder of the eye in which structural changes within the cornea cause it to thin and change to a more conical shape than its normal gradual curve....
, and at 10 years follow-up there was still no evidence of the inclusions in the stroma.