Florid cutaneous papillomatosis (also known as Schwartz-Burgess syndrome and FCP) is the sudden onset of numerous cutaneous papillomas that are indistinguishable from viral warts, and associated with underlying malignancy.

History

It was discovered by Robert A. Schwartz MD and Gordon H. Burgess MD. The original description was published in the Archives of Dermatology, which is published by American Medical Association

American Medical Association

The American Medical Association , founded in 1847 and incorporated in 1897, is the largest association of medical doctors and medical students in the United States.-Scope and operations:...

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Presentation

Florid cutaneous papillomatosis presents with verrucous papulonodules resembling viral warts. These skin lesions develop on the trunk, extremities, and face, and are almost twice as common in men than in women, especially individuals aged 53-72 years. This papillomatosis may also present with other cutaneous signs of internal malignancy, such as acanthosis nigricans type I and Leser-Trélat

Leser-Trelat sign

The Leser-Trélat sign is the explosive onset of multiple seborrheic keratoses , often with an inflammatory base. This can be an ominous sign of internal malignancy as part of a paraneoplastic syndrome...

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Etiology

Florid cutaneous papillomatosis is associated with underlying malignancy, most often gastric adenocarcinoma but also with breast cancer

Breast cancer

Breast cancer is cancer originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. Cancers originating from ducts are known as ductal carcinomas; those originating from lobules are known as lobular carcinomas...

, bladder cancer

Bladder cancer

Bladder cancer is any of several types of malignant growths of the urinary bladder. It is a disease in which abnormal cells multiply without control in the bladder. The bladder is a hollow, muscular organ that stores urine; it is located in the pelvis...

, hepatobiliary cancer, ovarian cancer

Ovarian cancer

Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early on and may include: bloating, pelvic pain, difficulty eating and frequent urination, and are easily confused with other illnesses....

, uterine cancer

Uterine cancer

The term uterine cancer may refer to any of several different types of cancer which occur in the uterus, namely:*Uterine sarcomas: sarcomas of the myometrium, or muscular layer of the uterus, are most commonly leiomyosarcomas.*Endometrial cancer:...

, prostate cancer

Prostate cancer

Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers. The cancer cells may metastasize from the prostate to other parts of the body, particularly...

, and lung cancer

Lung cancer

Lung cancer is a disease characterized by uncontrolled cell growth in tissues of the lung. If left untreated, this growth can spread beyond the lung in a process called metastasis into nearby tissue and, eventually, into other parts of the body. Most cancers that start in lung, known as primary...

; however, the cause of FCP is currently not known.

See also

• Papillomatosis
  Papillomatosis
  Papillomatosis is skin surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae.- See also :* Skin lesion* Skin disease* List of skin diseases* Papilloma* Laryngeal papillomatosis...
  
  
• Oral florid papillomatosis
  Oral florid papillomatosis
  Oral florid papillomatosis is a condition characterized by a white mass resembling a cauliflower covering the tongue and extending onto other portions of the mucous membranes. This is a type of verrucous carcinoma.- See also :* Mucous membrane...
  
  
• Familial cutaneous papillomatosis
• Skin lesion

External links

• New Zealand Dermatological Society