• Fluffy, stand-up comedian Gabriel Iglesias
  Gabriel Iglesias
  Gabriel J. Iglecias , known professionally as Gabriel Iglesias, is an American standup comedian and actor, known for his shows I’m Not Fat… I’m Fluffy and Hot & Fluffy.-Early life:...
  
  
• Fluffy (UAV), an unmanned aerial vehicle
• Fluffy transcription factor, a gene of the mold Neurospora crassa

Comics and literature

• Fluffy, a fictional cat character in the Disney comics series Darkwing Duck
• Fluffy (comics)
  Fluffy (comics)
  Fluffy is a graphic novel that was written and drawn by Simone Lia. It was first published as a series of four books between 2003 and 2005, and then released as one volume in 2007, by Jonathan Cape....
  
  , a graphic novel by Simone Lia
• Fluffy (Harry Potter), a giant three-headed dog in the novel Harry Potter and the Philosopher's Stone

Film and television

• Fluffy, a 1965 film starring Shirley Jones
  Shirley Jones
  Shirley Mae Jones is an American singer and actress of stage, film and television. In her six decades of television, she starred as wholesome characters in a number of well-known musical films, such as Oklahoma! , Carousel , and The Music Man...
  
  
• Fluffy, a 2003 short film starring Fred Ewanuick
  Fred Ewanuick
  Fred Ewanuick is a Canadian actor of Ukrainian and Italian heritage, known for his role in the television series Corner Gas as Hank Yarbo. He was also a regular in a CTV anthology series, Robson Arms.-Early life:...
  
  
• Fluffy, a fictional pet elephant belonging to the character Oscar the Grouch on the TV series Sesame Street

Music

• Fluffy, a 1990s band associated with the band Breakfast with Amy
  Breakfast with Amy
  Breakfast with Amy was an Alternative Christian rock band that formed in 1986 in La Habra, California at the La Habra Four-Square church. At that time, the band consisted of vocalist David Koval, bassist Jeff "Tennessee Beans" Beahn, guitarist Christopher Colbert, and drummer Paul Pellegrin. The...
  
  
• Fluffy (band)
  Fluffy (band)
  Fluffy was an all female punk rock band from London active between 1994 and 1998.-Origins:The band formed in 1994 after classmates, Amanda Rootes and Angie Adams were inspired by a jazz-blues singer in one of Old Compton Street's gay cafes. They were attending college in London at the time,...
  
  , a 1990s UK punk band