Fluoxymesterone
Encyclopedia
Fluoxymesterone is an anabolic steroid
with strong androgenic properties that has been used in the treatment of male hypogonadism
, delayed puberty in males, and in the treatment of breast neoplasms in women. It is approximately 5 times as potent as methyltestosterone
. The antitumor activity of fluoxymesterone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Like many C-17 alpha alkylated steroids, Fluoxymesterone (Halotestin) has poor binding to the AR. Even so, its actions are mediated by the androgen receptor, most-likely due to its prolonged plasma half-life.
Fluoxymesterone is only useful to a small select group of athletes who seeks very specific goals. Athletes tend to use it to increase strength and aggression in the gym or in competitions such as strongman contests or fighting (like boxing
or mixed martial arts
). The lack of estrogenic activity makes fluoxymesterone perfect for pre-fight usage – as weigh-ins would not be affected by water retention. Even in such an events, fluoxymesterone usage is usually limited to mere few weeks rather than cycled like real steroids for months. It is considered a very toxic oral drug, and a poor choice in most bodybuilding
/steroid use applications.
The half-life of fluoxymesterone is commonly misunderstood. The rumored belief is that 30–90 minutes is the half-life but this rumor is false, the half-life of Fluoxymesterone is about 9.2 hours.
http://dx.doi.org/10.1021/ja01583a073
Anabolic steroid
Anabolic steroids, technically known as anabolic-androgen steroids or colloquially simply as "steroids", are drugs that mimic the effects of testosterone and dihydrotestosterone in the body. They increase protein synthesis within cells, which results in the buildup of cellular tissue ,...
with strong androgenic properties that has been used in the treatment of male hypogonadism
Hypogonadism
Hypogonadism is a medical term for decreased functional activity of the gonads. Low testosterone is caused by a decline or deficiency in gonadal production of testosterone in males...
, delayed puberty in males, and in the treatment of breast neoplasms in women. It is approximately 5 times as potent as methyltestosterone
Methyltestosterone
Methyltestosterone is a 17-alpha-alkylated anabolic steroid used to treat men with a testosterone deficiency. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause...
. The antitumor activity of fluoxymesterone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Like many C-17 alpha alkylated steroids, Fluoxymesterone (Halotestin) has poor binding to the AR. Even so, its actions are mediated by the androgen receptor, most-likely due to its prolonged plasma half-life.
Fluoxymesterone is only useful to a small select group of athletes who seeks very specific goals. Athletes tend to use it to increase strength and aggression in the gym or in competitions such as strongman contests or fighting (like boxing
Boxing
Boxing, also called pugilism, is a combat sport in which two people fight each other using their fists. Boxing is supervised by a referee over a series of between one to three minute intervals called rounds...
or mixed martial arts
Mixed martial arts
Mixed Martial Arts is a full contact combat sport that allows the use of both striking and grappling techniques, both standing and on the ground, including boxing, wrestling, Brazilian jiu-jitsu, muay Thai, kickboxing, karate, judo and other styles. The roots of modern mixed martial arts can be...
). The lack of estrogenic activity makes fluoxymesterone perfect for pre-fight usage – as weigh-ins would not be affected by water retention. Even in such an events, fluoxymesterone usage is usually limited to mere few weeks rather than cycled like real steroids for months. It is considered a very toxic oral drug, and a poor choice in most bodybuilding
Bodybuilding
Bodybuilding is a form of body modification involving intensive muscle hypertrophy. An individual who engages in this activity is referred to as a bodybuilder. In competitive and professional bodybuilding, bodybuilders display their physiques to a panel of judges, who assign points based on their...
/steroid use applications.
The half-life of fluoxymesterone is commonly misunderstood. The rumored belief is that 30–90 minutes is the half-life but this rumor is false, the half-life of Fluoxymesterone is about 9.2 hours.
Synthesis
Herr, M. E.; Hogg, J. A.; Levin, R. H.; J. Amer. Chem. Soc. 1956, 78, 501.http://dx.doi.org/10.1021/ja01583a073