Folate receptor 1
Encyclopedia
Folate receptor alpha is a protein
that in humans is encoded by the FOLR1 gene
.
in phase III trial for ovarian cancer
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the FOLR1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Clinical significance
FRA can be overexpressed by a number of epithelial-derived tumors including ovarian, breast, renal, lung, colorectal, and brain. Hence antibodies to it are used targeted therapies and diagnostic tests, eg. farletuzumabFarletuzumab
Farletuzumab is a monoclonal antibody which is being investigated for the treatment of ovarian cancer.This drug was developed by Morphotek, Inc.It is targeted at FR-alpha which is overexpressed in some cancers such as ovarian cancer....
in phase III trial for ovarian cancer
Ovarian cancer
Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early on and may include: bloating, pelvic pain, difficulty eating and frequent urination, and are easily confused with other illnesses....
.