Frank Burr Mallory
Encyclopedia
Frank Burr Mallory was an American pathologist at the Boston City Hospital
Boston Medical Center
Boston Medical Center is a non-profit 639 licensed-bed medical center in Boston, Massachusetts. It was created by the formal merger of Boston City Hospital which was the first municipal hospital in the United States and Boston University Medical Center Hospital in July 1996 which was sponsored...

 and Professor of Pathology at Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....

, after whom the Mallory body
Mallory body
In histopathology, a Mallory body, Mallory-Denk body, and Mallory's hyaline, is an inclusion found in the cytoplasm of liver cells.-Associated conditions:...

 is named.

He was born in Cleveland, Ohio
Cleveland, Ohio
Cleveland is a city in the U.S. state of Ohio and is the county seat of Cuyahoga County, the most populous county in the state. The city is located in northeastern Ohio on the southern shore of Lake Erie, approximately west of the Pennsylvania border...

 on 12th November 1862, and received his medical degree in 1890 from Harvard Medical School. He became an assistant pathologist at Boston City Hospital in 1891, working under William Thomas Councilman. In 1893 he travelled to Europe to train under Hans Chiari
Hans Chiari
Hans Chiari was an Austrian pathologist who was a native of Vienna. He was the son of gynecologist Johann Baptist Chiari , and brother to rhinolaryngologist Ottokar Chiari ....

 in Prague
Prague
Prague is the capital and largest city of the Czech Republic. Situated in the north-west of the country on the Vltava river, the city is home to about 1.3 million people, while its metropolitan area is estimated to have a population of over 2.3 million...

 and Ernst Ziegler in Freiburg
University of Freiburg
The University of Freiburg , sometimes referred to in English as the Albert Ludwig University of Freiburg, is a public research university located in Freiburg im Breisgau, Baden-Württemberg, Germany.The university was founded in 1457 by the Habsburg dynasty as the...

.

After returning to Harvard, he became an Assistant Professor in 1896, and Associate Professor of Pathology in 1901. He became Professor of Pathology at Harvard Medical School from 1928 to 1932.

His contributions in the field of pathology included improving techniques and standardisation of tissue staining; his book, written with James Homer Wright
James Homer Wright
Dr. James Homer Wright was an early and influential American pathologist, who from 1896 to 1926 was chief of pathology at Massachusetts General Hospital. Wright was born in Pittsburgh, Pennsylvania....

, was the standard textbook in this field. He also studied the function of histiocytes
Histiocyte
A histiocyte is a cell that is part of the mononuclear phagocyte system . The mononuclear phagocytic system is part of the organism's immune system...

, he confirmed that the whooping cough
Pertussis
Pertussis, also known as whooping cough , is a highly contagious bacterial disease caused by Bordetella pertussis. Symptoms are initially mild, and then develop into severe coughing fits, which produce the namesake high-pitched "whoop" sound in infected babies and children when they inhale air...

 bacillus
Bordetella pertussis
Bordetella pertussis is a Gram-negative, aerobic coccobacillus of the genus Bordetella, and the causative agent of pertussis or whooping cough. Unlike B. bronchiseptica, B. pertussis is non-motile. Its virulence factors include pertussis toxin, filamentous hæmagglutinin, pertactin, fimbria, and...

 discovered by Jules Bordet
Jules Bordet
Jules Jean Baptiste Vincent Bordet was a Belgian immunologist and microbiologist. The bacterial genus Bordetella is named after him.-Biography:Bordet was born at Soignies, Belgium...

 was the causative agent, and he worked on improvements in classification of tumours, particularly meningiomas
Meningioma
The word meningioma was first used by Harvey Cushing in 1922 to describe a tumor originating from the meninges, the membranous layers surrounding the CNS ....

, and cirrhosis of the liver
Cirrhosis
Cirrhosis is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue and regenerative nodules , leading to loss of liver function...

.

He was president of the American Association of Pathologists and Bacteriologists
American Association of Pathologists and Bacteriologists
The American Association of Pathologists and Bacteriologists was an American national professional association established in 1901, devoted to the medical sciences as distinct from clinical medicine...

 in 1910, and was its treasurer from 1911 to 1940. He was the editor of the Journal of Medical Research from 1923, and then founding editor of the American Journal of Pathology from 1925 to 1940. He received honorary degrees from Tufts University
Tufts University
Tufts University is a private research university located in Medford/Somerville, near Boston, Massachusetts. It is organized into ten schools, including two undergraduate programs and eight graduate divisions, on four campuses in Massachusetts and on the eastern border of France...

 (Sc.D., 1928) and Boston University
Boston University
Boston University is a private research university located in Boston, Massachusetts. With more than 4,000 faculty members and more than 31,000 students, Boston University is one of the largest private universities in the United States and one of Boston's largest employers...

 (Sc.D., 1932), and was awarded the Kober medal in 1935 by the Association of American Physicians for outstanding service in pathology.

He died on 27th September 1941, aged 78. The pathology department at Boston City Hospital, the Mallory Institute of Pathology, was named after him.

One son, George Kenneth Mallory
George Kenneth Mallory
George Kenneth Mallory was an American pathologist chiefly remembered for describing the Mallory–Weiss tear.He was born in Boston, Massachusetts on 14 February 1900, the son of Frank Burr Mallory...

, became Professor of Pathology at Boston City Hospital in 1948, and the Mallory-Weiss syndrome
Mallory-Weiss syndrome
Mallory–Weiss syndrome or gastro-esophageal laceration syndrome refers to bleeding from tears in the mucosa at the junction of the stomach and esophagus, usually caused by severe retching, coughing, or vomiting.-Causes:...

is named after him. Another son, Tracy B. Mallory, was subsequently Chief of Pathology at Massachusetts General Hospital in Boston (succeeding James Homer Wright in 1926), and president of the American Association of Pathologists and Bacteriologists in 1951.
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