Fructose 6-phosphate
Encyclopedia
Fructose 6-phosphate is fructose
sugar phosphorylated on carbon 6 (i.e., is a fructosephosphate). The β-D-form of this compound is very common in cells
. The vast majority of glucose
and fructose entering a cell will become converted to this at some point. The name Neuberg ester comes from the German biochemist Carl Neuberg
.
found that the compound (only later identified as fructose 6-phosphate) could be produced by mild acid hydrolysis of "Harden-Young ester" (fructose 2,6-bisphosphate
).
metabolic pathway
and is produced by isomerisation of glucose 6-phosphate. It is in turn further phosphorylated to fructose-1,6-bisphosphate.
Fructose
Fructose, or fruit sugar, is a simple monosaccharide found in many plants. It is one of the three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion. Fructose was discovered by French chemist Augustin-Pierre Dubrunfaut in 1847...
sugar phosphorylated on carbon 6 (i.e., is a fructosephosphate). The β-D-form of this compound is very common in cells
Cell (biology)
The cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of life that is classified as a living thing, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos....
. The vast majority of glucose
Glucose
Glucose is a simple sugar and an important carbohydrate in biology. Cells use it as the primary source of energy and a metabolic intermediate...
and fructose entering a cell will become converted to this at some point. The name Neuberg ester comes from the German biochemist Carl Neuberg
Carl Neuberg
Carl Alexander Neuberg was an early pioneer in biochemistry, and often referred to as the "Father of Biochemistry".He was the first editor of the journal Biochemische Zeitschrift. This journal was founded in 1906 and is now known as the FEBS Journal. Neuberg was born in Hanover, Germany and...
.
History
In 1918, Carl NeubergCarl Neuberg
Carl Alexander Neuberg was an early pioneer in biochemistry, and often referred to as the "Father of Biochemistry".He was the first editor of the journal Biochemische Zeitschrift. This journal was founded in 1906 and is now known as the FEBS Journal. Neuberg was born in Hanover, Germany and...
found that the compound (only later identified as fructose 6-phosphate) could be produced by mild acid hydrolysis of "Harden-Young ester" (fructose 2,6-bisphosphate
Fructose 2,6-bisphosphate
Fructose 2,6-bisphosphate abbreviated Fru-2,6-P2, is a metabolite that allosterically affects the activity of the enzymes phosphofructokinase 1 and fructose 1,6-bisphosphatase to regulate glycolysis and gluconeogenesis...
).
Fructose 6-phosphate in glycolysis
Fructose 6-phosphate lies within the glycolysisGlycolysis
Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+...
metabolic pathway
Metabolic pathway
In biochemistry, metabolic pathways are series of chemical reactions occurring within a cell. In each pathway, a principal chemical is modified by a series of chemical reactions. Enzymes catalyze these reactions, and often require dietary minerals, vitamins, and other cofactors in order to function...
and is produced by isomerisation of glucose 6-phosphate. It is in turn further phosphorylated to fructose-1,6-bisphosphate.
See also
- Phosphofructokinase 2Phosphofructokinase 2Phosphofructokinase 2 or fructose biphosphatase 2 , is an enzyme responsible for regulating the rates of glycolysis and gluconeogenesis in the human body. It is a homodimer of 55 kDa subunits arranged in a head-to-head fashion, with each polypeptide chain consisting of independent kinase and...
is Fructose 2,6-bisphosphatase. This is one of the regulatory reactions of glycolysis. - Mannose phosphate isomeraseMannose phosphate isomeraseMannose-6 phosphate isomerase , alternately phosphomannose isomerase is an enzyme which facilitates the interconversion of fructose 6-phosphate and mannose-6-phosphate. Mannose-6-Phosphate Isomerase may also enable the synthesis of GDP-mannose in eukaryotic organisms...
creates mannose-6-phosphateMannose-6-phosphateMannose-6-phosphate is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphate by mannose phosphate isomerase....
.