Furoxan
Encyclopedia
Furoxan or 1,2,5-oxadiazole 2-oxide is a heterocycle of the isoxazole
family and an amine oxide
derivative of furazan. It is a nitric oxide
donor. As such, furoxan and its derivatives are actively researched as potential new drug
s and insensitive high density explosives.
Furoxanes can be formed by dimerization of nitrile oxides.
Isoxazole
Isoxazole is an azole with an oxygen atom next to the nitrogen. It is also the class of compounds containing this ring.Isoxazole rings are found in some natural products, such as ibotenic acid. Isoxazoles also form the basis for a number of drugs, including the COX-2 inhibitor valdecoxib...
family and an amine oxide
Amine oxide
An amine oxide, also known as amine-N-oxide and N-oxide, is a chemical compound that contains the functional group R3N+-O−, an N-O bond with three additional hydrogen and/or hydrocarbon side chains attached to N. Sometimes it is written as R3N→O or, wrongly, as R3N=O.In the strict sense the...
derivative of furazan. It is a nitric oxide
Nitric oxide
Nitric oxide, also known as nitrogen monoxide, is a diatomic molecule with chemical formula NO. It is a free radical and is an important intermediate in the chemical industry...
donor. As such, furoxan and its derivatives are actively researched as potential new drug
Drug
A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
s and insensitive high density explosives.
Furoxanes can be formed by dimerization of nitrile oxides.