Gamma-aminobutyric acid receptor-associated protein is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the GABARAP gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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A study has screened 2000 participants representing more than 600 families of smokers and examined different genes showing linkage to nicotine

Nicotine

Nicotine is an alkaloid found in the nightshade family of plants that constitutes approximately 0.6–3.0% of the dry weight of tobacco, with biosynthesis taking place in the roots and accumulation occurring in the leaves...

 addiction

Substance dependence

The section about substance dependence in the Diagnostic and Statistical Manual of Mental Disorders does not use the word addiction at all. It explains:...

. Some of these showing linkage are the GABA-B receptor subunit 2 (GABAB2) gene on chromosome 9, and the GABA-A receptor-associated protein (GABARAP) gene on chromosome 17.

Interactions

GABARAP has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with TFRC

TFRC

Transferrin receptor protein 1 also known as is a protein that in humans is encoded by the TFRC gene...

, ULK1

ULK1

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.-Interactions:ULK1 has been shown to interact with GABARAPL2, GABARAP, SYNGAP1 and SDCBP.-Further reading:...

 and GABRG2

GABRG2

Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene.-Interactions:GABRG2 has been shown to interact with GABARAP and Dopamine receptor D5.-Further reading:...

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Further reading