G protein-coupled receptor 55 also known as
GPR55 is a
G protein-coupled receptorG protein-coupled receptors , also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors , comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal...
that in humans is encoded by the
GPR55 geneA gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
GPR55, along with
GPR119G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the GPR119 gene.GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors.- Pharmacology :...
and
GPR18N-arachidonyl glycine receptor also known as G-protein coupled receptor 18 is a protein that in humans is encoded by the GPR18 gene...
, have been implicated as novel
cannabinoid receptorThe cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains...
s.
GPR55 was identified and cloned for the first time in 1999. Later it was identified by an
in silicoIn silico is an expression used to mean "performed on computer or via computer simulation." The phrase was coined in 1989 as an analogy to the Latin phrases in vivo and in vitro which are commonly used in biology and refer to experiments done in living organisms and outside of living organisms,...
screen as a putative cannabinoid receptor because of a similar amino acid sequence in the binding region.