GSK 299423
Encyclopedia
GSK 299423 or GlaxoSmithKline 299423 is an antibiotic
chemical compound that has been identified as potentially effective in treating patients infected with bacteria expressing the New Delhi metallo-beta-lactamase
. The antibiotic inhibits the enzyme topoisomerase
, which bacteria need to replicate.
No animal studies have been reported. No application has been made for human clinical trials.
Antibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
chemical compound that has been identified as potentially effective in treating patients infected with bacteria expressing the New Delhi metallo-beta-lactamase
New Delhi metallo-beta-lactamase
New Delhi metallo-beta-lactamase-1 is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotics. These include the antibiotics of the carbapenem family, which are a mainstay for the treatment of antibiotic-resistant bacterial infections...
. The antibiotic inhibits the enzyme topoisomerase
Topoisomerase
Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double helical structure. For example, during DNA replication, DNA becomes overwound ahead of a replication fork...
, which bacteria need to replicate.
No animal studies have been reported. No application has been made for human clinical trials.