Galega officinalis
Encyclopedia
Galega officinalis, commonly known as goat's rue, French lilac, Italian fitch or professor-weed, is an herbaceous plant in the Faboideae
subfamily. It is native to the Middle East
, but it has been naturalised in Europe
, western Asia
, and western Pakistan
. The plant has been extensively cultivated as a forage crop, an ornamental, a bee plant and as green manure
. Its name derives from gale (milk
) and ega (to bring on), as Galega has been used as a galactogogue in small domestic animals (hence the name "Goat's rue"). Galega bicolor is a synonym. It is a hardy perennial that blooms in the summer months.
Galega is used as a food plant by the larva
of Coleophora vicinella
, a species of moth
.
, for use as a forage crop. It escaped cultivation and is now a weed and agricultural pest, though it is still confined to that county. As a result it has been placed on the Federal Noxious Weed List in the United States
. It was collected in Colorado
, Connecticut
and New York
prior to the 1930s, and in Maine
and Pennsylvania
in the 1960s, but no more collections have been made in these areas since and the populations are presumed to have died out. It has also been found in Argentina
, Chile
, Ecuador
, and New Zealand
.
for relieving the symptoms of diabetes mellitus
. Upon analysis, it turned out to contain compounds related to guanidine
, a substance that decreases blood sugar
by mechanisms including a decrease in insulin resistance
, but were too toxic for human use. Georges Tanret identified an alkaloid from this plant, galegine, that was less toxic, and this was evaluated in unsuccessful clinical trials in patients with diabetes in the 1920s and 1930s.
Other related compounds were being investigated clinically at this time, including biguanide
derivatives. This work led ultimately to the discovery of metformin
(Glucophage), currently recommended in international guidelines for diabetes management as the first choice for antidiabetic pharmacotherapy alongside diet and exercise, and the older agent phenformin
, which has been withdrawn in most countries due to an unacceptable risk of lactic acidosis
(the risk of lactic acidosis with metformin is no higher than with other antidiabetic therapies when it is prescribed according to its label). The study of galegine and related molecules in the first half of the 20th century is regarded as an important milestone in the development of oral antidiabetic pharmacotherapy.
Goat's Rue is also cited by the SAS Survival Guide by John "Lofty" Wiseman, as having a sedative effect on fish. The roots and flowers are the most potent, but the most common method is to simply crush the entire plant and throw into a body of water with restricted flow. The fish that then float to the top are safe to consume.
Faboideae
Faboideae is a subfamily of the flowering plant family Fabaceae or Leguminosae. One acceptable alternative name for the subfamily is Papilionoideae....
subfamily. It is native to the Middle East
Middle East
The Middle East is a region that encompasses Western Asia and Northern Africa. It is often used as a synonym for Near East, in opposition to Far East...
, but it has been naturalised in Europe
Europe
Europe is, by convention, one of the world's seven continents. Comprising the westernmost peninsula of Eurasia, Europe is generally 'divided' from Asia to its east by the watershed divides of the Ural and Caucasus Mountains, the Ural River, the Caspian and Black Seas, and the waterways connecting...
, western Asia
Asia
Asia is the world's largest and most populous continent, located primarily in the eastern and northern hemispheres. It covers 8.7% of the Earth's total surface area and with approximately 3.879 billion people, it hosts 60% of the world's current human population...
, and western Pakistan
Pakistan
Pakistan , officially the Islamic Republic of Pakistan is a sovereign state in South Asia. It has a coastline along the Arabian Sea and the Gulf of Oman in the south and is bordered by Afghanistan and Iran in the west, India in the east and China in the far northeast. In the north, Tajikistan...
. The plant has been extensively cultivated as a forage crop, an ornamental, a bee plant and as green manure
Green manure
In agriculture, a green manure is a type of cover crop grown primarily to add nutrients and organic matter to the soil. Typically, a green manure crop is grown for a specific period of time , and then plowed under and incorporated into the soil while green or shortly after flowering...
. Its name derives from gale (milk
Milk
Milk is a white liquid produced by the mammary glands of mammals. It is the primary source of nutrition for young mammals before they are able to digest other types of food. Early-lactation milk contains colostrum, which carries the mother's antibodies to the baby and can reduce the risk of many...
) and ega (to bring on), as Galega has been used as a galactogogue in small domestic animals (hence the name "Goat's rue"). Galega bicolor is a synonym. It is a hardy perennial that blooms in the summer months.
Galega is used as a food plant by the larva
Larva
A larva is a distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle...
of Coleophora vicinella
Coleophora
Coleophora is a very large genus of moths of the family Coleophoridae. It contains some 1,350 described species. The genus is represented on all continents, but the majority are found in the Nearctic and Palaearctic regions...
, a species of moth
Moth
A moth is an insect closely related to the butterfly, both being of the order Lepidoptera. Moths form the majority of this order; there are thought to be 150,000 to 250,000 different species of moth , with thousands of species yet to be described...
.
Distribution
In 1891, goat's rue was introduced to Cache County, UtahUtah
Utah is a state in the Western United States. It was the 45th state to join the Union, on January 4, 1896. Approximately 80% of Utah's 2,763,885 people live along the Wasatch Front, centering on Salt Lake City. This leaves vast expanses of the state nearly uninhabited, making the population the...
, for use as a forage crop. It escaped cultivation and is now a weed and agricultural pest, though it is still confined to that county. As a result it has been placed on the Federal Noxious Weed List in the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
. It was collected in Colorado
Colorado
Colorado is a U.S. state that encompasses much of the Rocky Mountains as well as the northeastern portion of the Colorado Plateau and the western edge of the Great Plains...
, Connecticut
Connecticut
Connecticut is a state in the New England region of the northeastern United States. It is bordered by Rhode Island to the east, Massachusetts to the north, and the state of New York to the west and the south .Connecticut is named for the Connecticut River, the major U.S. river that approximately...
and New York
New York
New York is a state in the Northeastern region of the United States. It is the nation's third most populous state. New York is bordered by New Jersey and Pennsylvania to the south, and by Connecticut, Massachusetts and Vermont to the east...
prior to the 1930s, and in Maine
Maine
Maine is a state in the New England region of the northeastern United States, bordered by the Atlantic Ocean to the east and south, New Hampshire to the west, and the Canadian provinces of Quebec to the northwest and New Brunswick to the northeast. Maine is both the northernmost and easternmost...
and Pennsylvania
Pennsylvania
The Commonwealth of Pennsylvania is a U.S. state that is located in the Northeastern and Mid-Atlantic regions of the United States. The state borders Delaware and Maryland to the south, West Virginia to the southwest, Ohio to the west, New York and Ontario, Canada, to the north, and New Jersey to...
in the 1960s, but no more collections have been made in these areas since and the populations are presumed to have died out. It has also been found in Argentina
Argentina
Argentina , officially the Argentine Republic , is the second largest country in South America by land area, after Brazil. It is constituted as a federation of 23 provinces and an autonomous city, Buenos Aires...
, Chile
Chile
Chile ,officially the Republic of Chile , is a country in South America occupying a long, narrow coastal strip between the Andes mountains to the east and the Pacific Ocean to the west. It borders Peru to the north, Bolivia to the northeast, Argentina to the east, and the Drake Passage in the far...
, Ecuador
Ecuador
Ecuador , officially the Republic of Ecuador is a representative democratic republic in South America, bordered by Colombia on the north, Peru on the east and south, and by the Pacific Ocean to the west. It is one of only two countries in South America, along with Chile, that do not have a border...
, and New Zealand
New Zealand
New Zealand is an island country in the south-western Pacific Ocean comprising two main landmasses and numerous smaller islands. The country is situated some east of Australia across the Tasman Sea, and roughly south of the Pacific island nations of New Caledonia, Fiji, and Tonga...
.
Uses
Galega officinalis has been known since the Middle AgesMiddle Ages
The Middle Ages is a periodization of European history from the 5th century to the 15th century. The Middle Ages follows the fall of the Western Roman Empire in 476 and precedes the Early Modern Era. It is the middle period of a three-period division of Western history: Classic, Medieval and Modern...
for relieving the symptoms of diabetes mellitus
Diabetes mellitus
Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced...
. Upon analysis, it turned out to contain compounds related to guanidine
Guanidine
Guanidine is a crystalline compound of strong alkalinity formed by the oxidation of guanine. It is used in the manufacture of plastics and explosives. It is found in urine as a normal product of protein metabolism. The molecule was first synthesized in 1861 by the oxidative degradation of an...
, a substance that decreases blood sugar
Blood sugar
The blood sugar concentration or blood glucose level is the amount of glucose present in the blood of a human or animal. Normally in mammals, the body maintains the blood glucose level at a reference range between about 3.6 and 5.8 mM , or 64.8 and 104.4 mg/dL...
by mechanisms including a decrease in insulin resistance
Insulin resistance
Insulin resistance is a physiological condition where the natural hormone insulin becomes less effective at lowering blood sugars. The resulting increase in blood glucose may raise levels outside the normal range and cause adverse health effects, depending on dietary conditions. Certain cell types...
, but were too toxic for human use. Georges Tanret identified an alkaloid from this plant, galegine, that was less toxic, and this was evaluated in unsuccessful clinical trials in patients with diabetes in the 1920s and 1930s.
Other related compounds were being investigated clinically at this time, including biguanide
Biguanide
Biguanide can refer to a molecule, or to a class of drugs based upon this molecule. Biguanides can function as oral antihyperglycemic drugs used for diabetes mellitus or prediabetes treatment...
derivatives. This work led ultimately to the discovery of metformin
Metformin
Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function. Its use in gestational diabetes has been limited by safety concerns...
(Glucophage), currently recommended in international guidelines for diabetes management as the first choice for antidiabetic pharmacotherapy alongside diet and exercise, and the older agent phenformin
Phenformin
Phenformin is an anti-diabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases....
, which has been withdrawn in most countries due to an unacceptable risk of lactic acidosis
Lactic acidosis
Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate, and is considered a distinct form of metabolic acidosis. The condition typically occurs when cells receive too little oxygen , for example...
(the risk of lactic acidosis with metformin is no higher than with other antidiabetic therapies when it is prescribed according to its label). The study of galegine and related molecules in the first half of the 20th century is regarded as an important milestone in the development of oral antidiabetic pharmacotherapy.
Goat's Rue is also cited by the SAS Survival Guide by John "Lofty" Wiseman, as having a sedative effect on fish. The roots and flowers are the most potent, but the most common method is to simply crush the entire plant and throw into a body of water with restricted flow. The fish that then float to the top are safe to consume.
External links
- Taxonomy on NCBI (National Library of Medicine).
- Noxious Weed USDA Noxious & Invasive Weeds.