Gandy-Gamna nodules or Gandy-Gamna bodies are small yellow-brown, brown or rust-coloured foci found in the spleen in patients with splenomegaly due to portal hypertension

Portal hypertension

In medicine, portal hypertension is hypertension in the portal vein and its tributaries.It is often defined as a portal pressure gradient of 10 mmHg or greater.-Causes:Causes can be divided into prehepatic, intrahepatic, and posthepatic...

 and sickle cell disease. They consist of fibrous tissue with haemosiderin deposits, and probably form due to scarring

Scar

Scars are areas of fibrous tissue that replace normal skin after injury. A scar results from the biological process of wound repair in the skin and other tissues of the body. Thus, scarring is a natural part of the healing process. With the exception of very minor lesions, every wound results in...

 at sites of small perivascular haemorrhages

Bleeding

Bleeding, technically known as hemorrhaging or haemorrhaging is the loss of blood or blood escape from the circulatory system...

. They are visible on MRI scanning

Magnetic resonance imaging

Magnetic resonance imaging , nuclear magnetic resonance imaging , or magnetic resonance tomography is a medical imaging technique used in radiology to visualize detailed internal structures...

 due to the presence of haemosiderin.

They are named after Charles Gandy

Charles Gandy

Charles Gandy was a French physician remembered for Gandy-Gamna nodules.- External links :...

 and Carlos Gamna

Carlos Gamna

Carlos Gamna was an Italian physician remembered for Gandy-Gamna nodules and Gamna-Favre bodies.- External links :...

.