Ganirelix
Encyclopedia
Ganirelix acetate is an injectable gonadotropin-releasing hormone
antagonist (GnRH antagonist
). It is primarily used in assisted reproduction
to control ovulation
. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH
and FSH
. It is administered as a daily subcutaneous injection.
Ganirelix is marketed by Organon International
as Antagon.
Gonadotropin-releasing hormone
Gonadotropin-releasing hormone , also known as Luteinizing-hormone-releasing hormone and luliberin, is a tropic peptide hormone responsible for the release of follicle-stimulating hormone and luteinizing hormone from the anterior pituitary. GnRH is synthesized and released from neurons within...
antagonist (GnRH antagonist
Gonadotropin-releasing hormone antagonist
Gonadotrophin-releasing hormone antagonists are a class of compounds that are similar in structure to natural GnRH but that have an antagonistic effect. GnRH antagonists are peptide molecules that are made up multiple, often synthetically produced amino acids...
). It is primarily used in assisted reproduction
Reproductive technology
Reproductive technology encompasses all current and anticipated uses of technology in human and animal reproduction, including assisted reproductive technology, contraception and others.-Assisted reproductive technology:...
to control ovulation
Ovulation
Ovulation is the process in a female's menstrual cycle by which a mature ovarian follicle ruptures and discharges an ovum . Ovulation also occurs in the estrous cycle of other female mammals, which differs in many fundamental ways from the menstrual cycle...
. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH
Luteinizing hormone
Luteinizing hormone is a hormone produced by the anterior pituitary gland. In females, an acute rise of LH called the LH surge triggers ovulation and development of the corpus luteum. In males, where LH had also been called interstitial cell-stimulating hormone , it stimulates Leydig cell...
and FSH
Follicle-stimulating hormone
Follicle-stimulating hormone is a hormone found in humans and other animals. It is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation, and reproductive processes of the body. FSH and Luteinizing hormone act...
. It is administered as a daily subcutaneous injection.
Ganirelix is marketed by Organon International
Organon International
Organon is a human pharmaceutical company headquartered in Oss, Netherlands. In November 2007 the company became a part of Schering-Plough Corporation, acquired Organon, active pharmaceutical ingredient producer Diosynth , and its veterinary pharmaceutical sister company Intervet from Akzo Nobel. ...
as Antagon.