Generalized eruptive keratoacanthoma (also known as "Generalized eruptive keratoacanthoma of Grzybowski") is a cutaneous condition, a variant of keratoacanthoma

Keratoacanthoma

Keratoacanthoma is a common low-grade skin tumour that is believed to originate from the neck of the hair follicle. Many pathologists consider it to be a form of squamous cell carcinoma...

s, characterized by hundreds to thousands of tiny follicular keratotic papule

Papule

A papule is a circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to 1 cm.With regard to the quote "...varying in size from a pinhead to 1cm," depending on which text is referenced, some authors state the cutoff between a papule and a plaque as 0.5cm,...

s over the entire body.

Treatment

Treatments are not successful for many patients with Generalized eruptive keratoacanthoma. Use emollients and anti-itch medications can ease some symptoms. Improvement or complete resolutions of the condition has occurred with the application of the following medications:

• Acitretin
  Acitretin
  Acitretin is a second generation retinoid. It is taken orally, and is typically used for psoriasis....
  
  
• Isotretinoin
  Isotretinoin
  Isotretinoin, INN, is a medication used mostly for cystic acne. It was first developed for brain, pancreatic and other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. Its effects are systemic and nonselective...
  
  
• Fluorouracil
  Fluorouracil
  Fluorouracil is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites...
  
  
• Methotrexate
  Methotrexate
  Methotrexate , abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate...
  
  
• Cyclophosphamide
  Cyclophosphamide
  Cyclophosphamide , also known as cytophosphane, is a nitrogen mustard alkylating agent, from the oxazophorines group....
  
  

See also

• Keratoacanthoma
  Keratoacanthoma
  Keratoacanthoma is a common low-grade skin tumour that is believed to originate from the neck of the hair follicle. Many pathologists consider it to be a form of squamous cell carcinoma...
  
  
• Nail anatomy
  Nail (anatomy)
  A nail is a horn-like envelope covering the dorsal aspect of the terminal phalanges of fingers and toes in humans, most non-human primates, and a few other mammals. Nails are similar to claws, which are found on numerous other animals....
  
  
• List of cutaneous conditions