Glomerulation
Encyclopedia
Glomerulation refers to bladder
hemorrhages which are thought to be associated with some types of interstitial cystitis
(IC).
The presence of glomerulations, also known as petechial hemorrhages, in the bladder suggests that the bladder wall has been damaged, irritated and/or inflamed. In fact, the NIDDK Diagnostic Criteria for IC, developed in 1987, required the presence of glomerulations or Hunner's Ulcers
to make a firm diagnosis of IC and is still used, today, to determine patient eligibility for some clinical trials. Research conducted by Waxman, however, determined that the hydrodistention procedure itself may have created these tiny broken blood vessels. Thus, a diagnosis of IC is now based upon other, less invasive methods, such as the PUF questionnaire.
(such as all coffees, regular teas, green teas, sodas, diet sodas, artificial sugars and most fruit juices) should be avoided. The daily goal of patients should be to soothe rather than irritate the bladder wall.
Urinary bladder
The urinary bladder is the organ that collects urine excreted by the kidneys before disposal by urination. A hollow muscular, and distensible organ, the bladder sits on the pelvic floor...
hemorrhages which are thought to be associated with some types of interstitial cystitis
Interstitial cystitis
Interstitial cystitis or bladder pain syndrome is a chronic, oftentimes severely debilitating disease of the urinary bladder...
(IC).
The presence of glomerulations, also known as petechial hemorrhages, in the bladder suggests that the bladder wall has been damaged, irritated and/or inflamed. In fact, the NIDDK Diagnostic Criteria for IC, developed in 1987, required the presence of glomerulations or Hunner's Ulcers
Hunner's Ulcers
Hunner's Ulcers occur in 5 to 10 percent of people who have the disease Interstitial cystitis.They form on the wall of the bladder and, like any ulcer, they can bleed, ooze and vary in size. They were first described by Dr...
to make a firm diagnosis of IC and is still used, today, to determine patient eligibility for some clinical trials. Research conducted by Waxman, however, determined that the hydrodistention procedure itself may have created these tiny broken blood vessels. Thus, a diagnosis of IC is now based upon other, less invasive methods, such as the PUF questionnaire.
Treatment
In addition to traditional IC therapies, diet modification remains a core self care strategy as foods that are irritating to the bladder dramatically worsen the symptoms that patients may experience. Foods high in acid and/or caffeineCaffeine
Caffeine is a bitter, white crystalline xanthine alkaloid that acts as a stimulant drug. Caffeine is found in varying quantities in the seeds, leaves, and fruit of some plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding on the plants...
(such as all coffees, regular teas, green teas, sodas, diet sodas, artificial sugars and most fruit juices) should be avoided. The daily goal of patients should be to soothe rather than irritate the bladder wall.