Glycoprotein 100
Encyclopedia
Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a
type I transmembrane glycoprotein enriched in melanosomes
, which are the melanin-producing organelles in melanocytes
.
This protein is involved in melanosome maturation.
The gp100 protein is a melanoma
antigen
ie a tumor-specific antigen.
Short fragments of it have been used to develop the gp100 cancer vaccine
which is or contains gp100:209-217(210M)
.
Hydrophilic recombinant gp100 protein (HR-gp100) has been topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. It was demonstrated that HR-gp100 permeates into human skin, and is processed and presented by human dendritic cells. In the mouse model, an HR-gp100-based vaccine triggered antigen-specific T cell responses, as shown by proliferation assays, ELISA and intracellular staining for IFN-γ.
type I transmembrane glycoprotein enriched in melanosomes
Melanosome
In a biological cell, a melanosome is an organelle containing melanin, the most common light-absorbing pigment found in the animal kingdom.Cells that synthesize melanins are called melanocytes, and also the retinal pigment epithelium cells, whereas cells that have merely engulfed the melanosomes...
, which are the melanin-producing organelles in melanocytes
Melanocyte
-External links: - "Eye: fovea, RPE" - "Integument: pigmented skin"...
.
This protein is involved in melanosome maturation.
The gp100 protein is a melanoma
Melanoma
Melanoma is a malignant tumor of melanocytes. Melanocytes are cells that produce the dark pigment, melanin, which is responsible for the color of skin. They predominantly occur in skin, but are also found in other parts of the body, including the bowel and the eye...
antigen
Antigen
An antigen is a foreign molecule that, when introduced into the body, triggers the production of an antibody by the immune system. The immune system will then kill or neutralize the antigen that is recognized as a foreign and potentially harmful invader. These invaders can be molecules such as...
ie a tumor-specific antigen.
Short fragments of it have been used to develop the gp100 cancer vaccine
Cancer vaccine
The term cancer vaccine refers to a vaccine that either prevents infections with cancer-causing viruses, treats existing cancer or prevents the development of cancer in certain high risk individuals...
which is or contains gp100:209-217(210M)
Gp100:209-217(210M)
Gp100:209-217 is a synthetic peptide cancer vaccine consisting of amino acid residues 209 through 217 of the glycoprotein 100 melanoma antigen, with a methionine substitution at position 210...
.
Hydrophilic recombinant gp100 protein (HR-gp100) has been topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. It was demonstrated that HR-gp100 permeates into human skin, and is processed and presented by human dendritic cells. In the mouse model, an HR-gp100-based vaccine triggered antigen-specific T cell responses, as shown by proliferation assays, ELISA and intracellular staining for IFN-γ.