in the TGF beta signaling pathway
.
Gremlin, also known as Drm, is a highly conserved 20.7-kDa, 184 amino acid glycoprotein
part of the DAN family and is a cysteine knot-secreted protein. Gremlin was first identified in differential screening as a transcriptional down-regulated gene in v-mos-transformed rat embryonic fibrolasts.
Gremlin 1 (grem 1) is known for its antagonistic reaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling pathway
.
Most people think time is like a river that flows swift and sure in one direction. But I have seen the face of time, and I can tell you: they are wrong. Time is an ocean in a storm. You may wonder who I am or why I say this. Sit down and I will tell you a tale like none you have ever heard. [First and Last lines in the Trilogy].
Father, I have brought us honour and glory.
Trust not a man who has betrayed his master, nor take him into your own service, lest he betray you too. I learned the truth of this, to my sorrow, the day we arrived in Azad as the Sultan's honoured guests.
When a man is faced with his own death, he finds the impossible less of a barrier.
He now had his prize, but for some unknown reason coveted the Dagger as well. Well, I would give him what he sought. I would plunge it into his foul and treacherous heart!
I could marry her! After all, she is a Maharajah's daughter. A conquered one, but still, her blood is royal. . . . All right, I've decided. I will marry her. I'll tell her the first chance I get.
My father's army sacked your palace, captured you as a slave; you have every reason to hate me...now you want me to trust you?
I had faced my enemy, I had looked into his eyes, and I had lost...everything.
....and though I fought until the desert sands themselves were red with blood; I could not bring back the dead.