Gremlin (protein)
Overview
 
Gremlin is an inhibitor
Enzyme inhibitor
An enzyme inhibitor is a molecule that binds to enzymes and decreases their activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. They are also used as herbicides and pesticides...

 in the TGF beta signaling pathway
TGF beta signaling pathway
The Transforming growth factor beta signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular...

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Gremlin, also known as Drm, is a highly conserved 20.7-kDa, 184 amino acid glycoprotein
Glycoprotein
Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...

 part of the DAN family and is a cysteine knot-secreted protein. Gremlin was first identified in differential screening as a transcriptional down-regulated gene in v-mos-transformed rat embryonic fibrolasts.

Gremlin 1 (grem 1) is known for its antagonistic reaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling pathway
TGF beta signaling pathway
The Transforming growth factor beta signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular...

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Quotations

Most people think time is like a river that flows swift and sure in one direction. But I have seen the face of time, and I can tell you: they are wrong. Time is an ocean in a storm. You may wonder who I am or why I say this. Sit down and I will tell you a tale like none you have ever heard. [First and Last lines in the Trilogy].

Father, I have brought us honour and glory.

Trust not a man who has betrayed his master, nor take him into your own service, lest he betray you too. I learned the truth of this, to my sorrow, the day we arrived in Azad as the Sultan's honoured guests.

When a man is faced with his own death, he finds the impossible less of a barrier.

He now had his prize, but for some unknown reason coveted the Dagger as well. Well, I would give him what he sought. I would plunge it into his foul and treacherous heart!

I could marry her! After all, she is a Maharajah's daughter. A conquered one, but still, her blood is royal. . . . All right, I've decided. I will marry her. I'll tell her the first chance I get.

My father's army sacked your palace, captured you as a slave; you have every reason to hate me...now you want me to trust you?

I had faced my enemy, I had looked into his eyes, and I had lost...everything.

....and though I fought until the desert sands themselves were red with blood; I could not bring back the dead.

 
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