Group-specific antigen
Encyclopedia
Group-specific antigen is the genetic material that codes for the core structural proteins of a retrovirus
.
It comprises part of the gag-onc fusion protein
.
Gag proteins are encoded by the gag gene, and provide structural elements of the virus.
When a Western blot
test is used to detect HIV infection, p24 is one of the three major proteins tested for, along with gp120/gp160 and gp41.
p17 provides a protective matrix (a protein that forms a scaffold during virion assembly).
Retrovirus
A retrovirus is an RNA virus that is duplicated in a host cell using the reverse transcriptase enzyme to produce DNA from its RNA genome. The DNA is then incorporated into the host's genome by an integrase enzyme. The virus thereafter replicates as part of the host cell's DNA...
.
It comprises part of the gag-onc fusion protein
Gag-onc fusion protein
The gag-onc fusion protein is a protein formed from a group-specific antigen and that of an oncovirus , such as C-jun....
.
Gag in HIV
p24
p24 makes up the viral capsid.When a Western blot
Western blot
The western blot is a widely used analytical technique used to detect specific proteins in the given sample of tissue homogenate or extract. It uses gel electrophoresis to separate native proteins by 3-D structure or denatured proteins by the length of the polypeptide...
test is used to detect HIV infection, p24 is one of the three major proteins tested for, along with gp120/gp160 and gp41.
p6, p7, and p17
p6 and p7 provide the nucleocapsid.p17 provides a protective matrix (a protein that forms a scaffold during virion assembly).