Günter Blobel
Encyclopedia
Biography
Blobel was born in Waltersdorf in the PrussiaPrussia
Prussia was a German kingdom and historic state originating out of the Duchy of Prussia and the Margraviate of Brandenburg. For centuries, the House of Hohenzollern ruled Prussia, successfully expanding its size by way of an unusually well-organized and effective army. Prussia shaped the history...
n Province of Lower Silesia
Province of Lower Silesia
The Province of Lower Silesia was a province of the Free State of Prussia from 1919 to 1945. Between 1938 and 1941 it was reunited with Upper Silesia as the Silesia Province. The capital of Lower Silesia was Breslau...
. In January 1945 his family fled from native Silesia from the advancing Red Army. On their way to the West they passed through the beautiful old city of Dresden
Dresden
Dresden is the capital city of the Free State of Saxony in Germany. It is situated in a valley on the River Elbe, near the Czech border. The Dresden conurbation is part of the Saxon Triangle metropolitan area....
, which left deep impressions in the young boy. Only days after their stay Dresden was destroyed in the catastrophic air bombing
Bombing of Dresden in World War II
The Bombing of Dresden was a military bombing by the British Royal Air Force and the United States Army Air Force and as part of the Allied forces between 13 February and 15 February 1945 in the Second World War...
between 13 February and 15 February 1945. The family could witness this event some 30 kilometers away and the young boy again was deeply impressed by the red night sky reflecting the firestorm in the burning city, but the war was still not at its end and Blobel's 19-year-old sister was killed some weeks later in an air attack on a train she was travelling in, and buried in a mass grave.
After the war Günter Blobel grew up and attended gymnasium
Gymnasium (school)
A gymnasium is a type of school providing secondary education in some parts of Europe, comparable to English grammar schools or sixth form colleges and U.S. college preparatory high schools. The word γυμνάσιον was used in Ancient Greece, meaning a locality for both physical and intellectual...
in the Saxon
Saxony
The Free State of Saxony is a landlocked state of Germany, contingent with Brandenburg, Saxony Anhalt, Thuringia, Bavaria, the Czech Republic and Poland. It is the tenth-largest German state in area, with of Germany's sixteen states....
town of Freiberg
Freiberg, Saxony
Freiberg is a city in the Free State of Saxony, Germany, administrative center of the Mittelsachsen district.-History:The city was founded in 1186, and has been a center of the mining industry in the Ore Mountains for centuries...
. He graduated at the University of Tübingen in 1960 and received his Ph.D. from the University of Wisconsin–Madison
University of Wisconsin–Madison
The University of Wisconsin–Madison is a public research university located in Madison, Wisconsin, United States. Founded in 1848, UW–Madison is the flagship campus of the University of Wisconsin System. It became a land-grant institution in 1866...
in 1967. He was appointed to the Howard Hughes Medical Institute
Howard Hughes Medical Institute
Howard Hughes Medical Institute is a United States non-profit medical research organization based in Chevy Chase, Maryland. It was founded by the American businessman Howard Hughes in 1953. It is one of the largest private funding organizations for biological and medical research in the United...
in 1986.
Blobel was awarded the 1999 Nobel Prize in Physiology or Medicine
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the field of life science and medicine. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will...
for the discovery of signal peptides. Signal peptides form an integral part of protein targeting
Protein targeting
Protein targeting or protein sorting is the mechanism by which a cell transports proteins to the appropriate positions in the cell or outside of it. Sorting targets can be the inner space of an organelle, any of several interior membranes, the cell's outer membrane, or its exterior via secretion...
, a mechanism for cells to direct newly synthesized protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
molecules to their proper location by means of an "address tag" (i.e. a signal peptide) within the molecule.
Blobel is also well known for his direct and active support for the rebuilding of Dresden
Dresden
Dresden is the capital city of the Free State of Saxony in Germany. It is situated in a valley on the River Elbe, near the Czech border. The Dresden conurbation is part of the Saxon Triangle metropolitan area....
in Germany
Germany
Germany , officially the Federal Republic of Germany , is a federal parliamentary republic in Europe. The country consists of 16 states while the capital and largest city is Berlin. Germany covers an area of 357,021 km2 and has a largely temperate seasonal climate...
, becoming, in 1994, the founder and president of the nonprofit "Friends of Dresden, Inc." He donated all of the Nobel award money to the restoration of Dresden, in particular for the rebuilding of the Frauenkirche
Dresden Frauenkirche
The Dresden Frauenkirche is a Lutheran church in Dresden, eastern Germany.Built in the 18th century, the church was destroyed in the firebombing of Dresden during World War II. It has been reconstructed as a landmark symbol of reconciliation between former warring enemies...
(completed in 2005) and the building of a new synagogue
Synagogue
A synagogue is a Jewish house of prayer. This use of the Greek term synagogue originates in the Septuagint where it sometimes translates the Hebrew word for assembly, kahal...
. In Leipzig he pursued a rebuilding of the Paulinerkirche
Paulinerkirche, Leipzig
The Paulinerkirche was a church on the Augustusplatz in Leipzig, named after the "Pauliner", its original Dominican friars. It was built in 1231 as the Klosterkirche St. Pauli for the Dominican monastery in Leipzig. From the foundation of the University of Leipzig in 1409, it served as the...
which had been blown up by the communist regime of East Germany in 1968, arguing: "This is much more than a church — this is a shrine of German cultural history, connected to the most important names in German cultural history."
Blobel has worked at the Rockefeller University
Rockefeller University
The Rockefeller University is a private university offering postgraduate and postdoctoral education. It has a strong concentration in the biological sciences. It is also known for producing numerous Nobel laureates...
in New York City
New York City
New York is the most populous city in the United States and the center of the New York Metropolitan Area, one of the most populous metropolitan areas in the world. New York exerts a significant impact upon global commerce, finance, media, art, fashion, research, technology, education, and...
since 1968. He lives in Manhattan
Manhattan
Manhattan is the oldest and the most densely populated of the five boroughs of New York City. Located primarily on the island of Manhattan at the mouth of the Hudson River, the boundaries of the borough are identical to those of New York County, an original county of the state of New York...
's Upper East Side
Upper East Side
The Upper East Side is a neighborhood in the borough of Manhattan in New York City, between Central Park and the East River. The Upper East Side lies within an area bounded by 59th Street to 96th Street, and the East River to Fifth Avenue-Central Park...
with his wife and three English setter
English Setter
The English Setter is a breed of dog. It is part of the Setter family, which includes red Irish Setters, Irish Red and White Setters, and black-and-tan Gordon Setters. It is a gun dog, bred for a mix of endurance and athleticism.- Appearance :...
dogs. He is also on the board of directors for Nestlé
Nestlé
Nestlé S.A. is the world's largest food and nutrition company. Founded and headquartered in Vevey, Switzerland, Nestlé originated in a 1905 merger of the Anglo-Swiss Milk Company, established in 1867 by brothers George Page and Charles Page, and Farine Lactée Henri Nestlé, founded in 1866 by Henri...
and the Board of Scientific Governors at The Scripps Research Institute
The Scripps Research Institute
The Scripps Research Institute is an American medical research facility that focuses on research in the basic biomedical sciences. Headquartered in La Jolla, California, with a sister facility in Jupiter, Florida, the institute is home to 3,000 scientists, technicians, graduate students, and...
. Furthermore, he is also Co-Founder and Chairman of the Scientific Advisory Board for Chromocell Corporation.
Scientific awards
- 1978: National Academy of SciencesUnited States National Academy of SciencesThe National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...
' U.S. Steel Foundation Award in Molecular Biology - 1982: Gairdner Foundation International AwardGairdner Foundation International AwardThe Gairdner Foundation International Award is given annually at a special dinner to three to six people for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a precursor to winning the Nobel Prize in Medicine; as of 2007, 69 Nobel...
- 1987: Louisa Gross Horwitz PrizeLouisa Gross Horwitz PrizeLouisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers that have made an outstanding contribution in basic research in the fields of biology or biochemistry....
from Columbia UniversityColumbia UniversityColumbia University in the City of New York is a private, Ivy League university in Manhattan, New York City. Columbia is the oldest institution of higher learning in the state of New York, the fifth oldest in the United States, and one of the country's nine Colonial Colleges founded before the... - 1993: Albert Lasker Award for Basic Medical ResearchAlbert Lasker Award for Basic Medical ResearchThe Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for the understanding, diagnosis, prevention, treatment, and cure of disease...
- 1995: Ciba Drew Award in Biomedical Research
- 1996: King Faisal Award
- 1997: Mayor's Award for Excellence in Science and TechnologyMayor's Award for Excellence in Science and TechnologyThe Mayor's Award for Excellence in Science and Technology is given annually to recognise important members of the science and engineering communities in New York City...
- 1999: Nobel Prize in Physiology or MedicineNobel Prize in Physiology or MedicineThe Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the field of life science and medicine. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will...
- 2001: Pontifical Academy of SciencesPontifical Academy of SciencesThe Pontifical Academy of Sciences is a scientific academy of the Vatican, founded in 1936 by Pope Pius XI. It is placed under the protection of the reigning Supreme Pontiff. Its aim is to promote the progress of the mathematical, physical and natural sciences and the study of related...
Citations
"You are one, they are many. If you don't work hard night and day, they will crush you like a roach"External links
- Blobel's page at Rockefeller University
- Blobel's Nobel Prize autobiography
- Freeview video 'An Interview with Günter Blobel' by the Vega Science Trust
- Official site of the Louisa Gross Horwitz Prize
- Information about Blobel as Distinguished German-American of the Year 2005 (German-American Heritage Foundation)