HLA-A10 is a broad antigen HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-A

HLA-A

HLA-A are a group of human leukocyte antigens that are encoded by the HLA-A locus on human chromosome 6p. The HLA genes constitute a large subset of the Major histocompatibility complex of humans. HLA-A is a component of certain MHC class I cell surface receptor isoforms that resides on the...

 serotype. The ancestral A10 type is believed to be A*2601, which via gene conversion

Gene conversion

Gene conversion is an event in DNA genetic recombination, which occurs at high frequencies during meiotic division but which also occurs in somatic cells. It is a process by which DNA sequence information is transferred from one DNA helix to another DNA helix, whose sequence is altered.It is one...

 with other HLA-A

HLA-A

HLA-A are a group of human leukocyte antigens that are encoded by the HLA-A locus on human chromosome 6p. The HLA genes constitute a large subset of the Major histocompatibility complex of humans. HLA-A is a component of certain MHC class I cell surface receptor isoforms that resides on the...

 allele

Allele

An allele is one of two or more forms of a gene or a genetic locus . "Allel" is an abbreviation of allelomorph. Sometimes, different alleles can result in different observable phenotypic traits, such as different pigmentation...

s produced A*2501

HLA-A25

-A25 frequencies:A*2501 distribution is primarily located in Western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source....

, A*3401

HLA-A34

-A*3401:A*3401 when found outside of Africa is primarily found in the South Asia, Austronesia and the South/Central part of the West Pacific Rim . It appears to have made it to Eastern Taiwan's indigenous tribes but not more north of this region. It has not been detected in any sampling of Japan...

, A*4301

HLA-A43

-Distribution:...

 and A*6601

HLA-A66

-A*6601 Frequencies:...

. A10 serotypes in general show a pattern of more recent expansion. A34 is an excellent example, appearing to have expanded from the middle east, with linkage disequilibrium with B alleles into Austronesia, South Pacific, Philippines and as far north as Taiwan (where it is found in the Taiwan Ami and Yami tribal groups but rare in ethnic Chinese nor in Hong Kong Chinese). A*66 appears to have expanded from North Africa into the Middle East or Europe and A26 appears to have expanded Black Sea and, after the initial settlement from the southern West Pacific Rim peoples, into Japan . Whether this is a secondary migration from Africa or a re-expansion from within Eurasia is unclear.
|+ Subpages for A10 serotypes
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| colspan = "4" | Serotypes of A10 gene products
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| HLA-A25

HLA-A25

-A25 frequencies:A*2501 distribution is primarily located in Western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source....

|-
| HLA-A26

HLA-A26

-Distribution:-Disease associations:A26 Serotype is associated with adult T-cell leukemia in Japanese....

|-
| HLA-A34

HLA-A34

-A*3401:A*3401 when found outside of Africa is primarily found in the South Asia, Austronesia and the South/Central part of the West Pacific Rim . It appears to have made it to Eastern Taiwan's indigenous tribes but not more north of this region. It has not been detected in any sampling of Japan...

|-
| HLA-A43

HLA-A43

-Distribution:...

|-
| HLA-A66

HLA-A66

-A*6601 Frequencies:...

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