HLA-B51
Encyclopedia
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| B*5101-β2MG with bound peptide | ||
| Alleles | B*5101, 5102, 5103, . . . | |
| Structure (See HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex... ) |
Available3D structures | |
| EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
B*5101 | , |
HLA-B51 (B51) is an HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...
-B
HLA-B
HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...
serotype
Serotype
Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...
. The serotype identifies the more common HLA-B*51 gene products.
B51 is a split antigen of the broad antigen B5
HLA-B5
HLA-B5 is an HLA-B serotype. B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen serotypes.-Serotype:...
, and is a sister serotype of B52
HLA-B52
HLA-B52 is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.B52 is a split antigen of the broad antigen B5, and is a sister type of B51...
. There are a large number of alleles within the B*51 allele group. B51 is associated with several diseases, including Behçet's disease
Behçet's disease
Behçet's disease is a rare immune-mediated systemic vasculitis that often presents with mucous membrane ulceration and ocular involvements...
.
Serotype
| B*51 | B51 | B5 | B52 | B53 | Sample |
| allele | % | % | % | % | size (N) |
| 96 | 2 | 1 | 1899 | ||
| 73 | 3 | 6 | 11 | 218 | |
| 83 | 17 | 6 | |||
| 48 | 16 | 24 | 25 | ||
| 64 | 7 | 12 | 42 | ||
| 78 | 9 | 68 | |||
| 77 | 3 | 154 | |||
| 86 | 43 | ||||
| B} also reacts to B5102 - 3%, } with B5103 | |||||
| Alleles link-out to IMGT/HLA Human leukocyte antigen The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and... Databease at EBI European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
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Alleles
There are 71 alleles, 57 amino acid sequence variants in B51 of which 4 are nulls. Of these only 9 are frequent enough to have been reliably serotyped. B*5101 is the most common, but others have a large regional abundance.| freq | ||
| ref. | Population | (%) |
| Bulgaria | 20.9 | |
| Georgia Tibilisi Georgians | 15.7 | |
| India Tamil Nadu Nadar | 15.6 | |
| China North Han | 14.8 | |
| Georgia Tibilisi Kurds | 12.1 | |
| India Andhra Pradesh Golla | 12.0 | |
| China Qinghai Hui | 11.4 | |
| India New Delhi | 9.8 | |
| Madeira | 9.7 | |
| South Africa Natal Tamil | 9.2 | |
| USA Hawaii Okinawa | 8.7 | |
| Cape Verde Northwestern Islands | 8.1 | |
| Cape Verde Southeastern Islands | 7.3 | |
| India Mumbai Marathas | 6.8 | |
| Russia Tuva pop 2 | 6.1 | |
| Israel Arab Druse | 6.0 | |
| China Inner Mongolia | 5.9 | |
| Czech Republic | 5.7 | |
| Finland | 5.6 | |
| Iran Baloch | 8.1 | |
| Brazil | 5.1 | |
| Mexico Guadalajara Mestizos | 4.9 | |
| New Mexico Canoncito Navajo | 4.9 | |
| China South Han | 4.6 | |
| India North Hindus | 3.8 | |
| Thailand | 3.1 | |
| Ivory Coast Akan Adiopodoume | 2.3 | |
| Singapore Chinese Han | 2.3 | |
| Singapore Javanese Indonesians | 2.0 | |
| Taiwan Saisiat | 2.0 | |
| Kenya | 1.7 | |
| Cameroon Yaounde | 1.6 | |
| Senegal Niokholo Mandenka | 1.6 | |
| Guinea Bissau | 1.5 | |
| USA Arizona Pima | 1.1 | |
| Venezuela Perja Mountain Bari | 1.1 | |
| Taiwan Pazeh | 0.9 | |
| China Guangdong Meizhou Han | 0.5 | |
| Israel Ashk. & Non Ashk. Jews | 0.5 | |
| Singapore Thai | 3.0 | |
| Iran Baloch | 1.0 | |
| USA Asian | 1.0 |
By serotype
Bw51 was associated with Behçet's diseaseBehçet's disease
Behçet's disease is a rare immune-mediated systemic vasculitis that often presents with mucous membrane ulceration and ocular involvements...
, in endemic (versus epidemic) mucocutaneous lymph node syndrome, susceptibility to the virus that causes
Rubella virus
Rubella virus is the pathogenic agent of the disease Rubella, and is the cause of congenital rubella syndrome when infection occurs during the first weeks of lunacy.Humans are the only known host of this virus....
German measles infection.
| freq | ||
| ref. | Population | (%) |
| Mexico Sonora Seri | 1.5 | |
| Thailand | 1.4 | |
| Singapore Chinese | 1.3 | |
| Hong Kong Chinese | 1.0 | |
| USA Natives | 0.8 | |
| Mexico Zaptotec Oaxaca | 0.7 | |
| South Korea pop 3 | 0.6 | |
| Shijiazhuang Tianjian Han | 0.5 | |
| China Guangxi Maonan | 0.5 | |
| Japan (5) | 0.4 | |
| USA Asian | 0.4 | |
| USA Hispanic | 0.4 | |
| USA African America | 0.2 |
In Behçet's Disease
Behçet's disease is an inflammation of the wall of blood vesselsVasculitis
Vasculitis refers to a heterogeneous group of disorders that are characterized by inflammatory destruction of blood vessels. Both arteries and veins are affected. Lymphangitis is sometimes considered a type of vasculitis...
that can involve the eyes, skin, and the rest of the body. Several alleles of B51 (B*5101, B*5108, B*5105, and B*5104) are found in disease, and linkage to markers, D6S285, in the HLA locus was strong (P>0.005). Homozygotes of B51 showed considerably high risk for disease indicating a possible gene-dose effect. B51 is capable of distinguishing several varieties of disease. HLA-B51 is found more frequently in disease that has an eye involvement. However it is less common in some regions when there is increased neurological involvement. The MICA
MHC class I polypeptide-related sequence A
MHC class I polypeptide-related sequence A is a protein that in humans is encoded by the MICA gene.-Further reading:...
*009 allele has been found to also associated with ABD when B51 is also present, IL-8 and other cytokines may also be involved. Sister chromatid exchange
Sister chromatid exchange
Sister chromatid exchange is the exchange of genetic material between two identical sister chromatids.It was first discovered by using the Giemsa staining method on one chromatid belonging to the sister chromatid complex before anaphase in mitosis...
has also been observed more frequently in B51(+) ABD.
However, B51 tends not to be found in ABD when a certain SUMO4
SUMO4
Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene.-Further reading:...
gene variant is involved, and symptoms appear to be milder when HLA-B27
HLA-B27
Human Leukocyte Antigen B27 is a class I surface antigen encoded by the B locus in the major histocompatibility complex on chromosome 6 and presents antigenic peptides to T cells...
is present.