Haplotypes groups	DRA*01:DRB1*0302 DRA*01:DRB5*0303
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB1
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB5*0302
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*0303
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR18 (DR18) is a HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.

Serology

DR18 recognition of some DRB1*03 alleles

DRB1*	DR18	DR3	DR17	Sample
allele	%	%	%	size (N)
0302	66	24	3	317
0303	60	40		5

DR18 recognizes the DRB1*0302 and *0303, the thoroughness of recognition is fair, but better than DR3.









Disease associations=
DR18 seropositivity is associated with rheumatoid polyarthritis

DRB1*0302 is positively associated with juvenile diabetes

Diabetes mellitus type 1

Diabetes mellitus type 1 is a form of diabetes mellitus that results from autoimmune destruction of insulin-producing beta cells of the pancreas. The subsequent lack of insulin leads to increased blood and urine glucose...

, nuclear helicase Mi-2 autoantibodies in inflammatory inclusion body myositis.
Genetic Linkage=

Serotypes	DRA	DRB1	| DRB3
DR18(3)-DR52	*0101	*0302	*0101
	DQA1	DQB1	| DRB1
D18(3)-DQ2(2.5)	*0501	*0201	*0302
	HLA-A	HLA -B	| DRB1
A33-B58-DR18(3)	*3301	*5801	*0302

HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes
are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.