HNRPA2B1
Encyclopedia
Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein
that in humans is encoded by the HNRNPA2B1 gene
.
HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis
, systemic lupus erythematosus
and mixed connective tissue disease
. When referred to as an autoantigen, hnRNPA2B1 is also known as RA33
.
with Casein kinase 2, alpha 1.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the HNRNPA2B1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis
Rheumatoid arthritis
Rheumatoid arthritis is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium secondary to hyperplasia of synovial cells, excess synovial fluid, and the development...
, systemic lupus erythematosus
Systemic lupus erythematosus
Systemic lupus erythematosus , often abbreviated to SLE or lupus, is a systemic autoimmune disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage...
and mixed connective tissue disease
Mixed connective tissue disease
In medicine, mixed connective tissue disease , commonly abbreviated as MCTD, is an autoimmune disease, in which the body's defense system attacks itself. It was characterized in 1972....
. When referred to as an autoantigen, hnRNPA2B1 is also known as RA33
RA33
RA33, also known as heterogeneous nuclear ribonucleoprotein A2/B1 is an autoantigen in human autoimmune diseases.In 1989, a novel class of autoantibodies were detected in sera of patients with rheumatoid arthritis which were directed to a protein with an estimated molecular mass of approximately...
.
Interactions
HNRPA2B1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Casein kinase 2, alpha 1.