Hapuseneb was the High Priest of Amun during the reign of Hatshepsut

Hatshepsut

Hatshepsut also Hatchepsut; meaning Foremost of Noble Ladies;1508–1458 BC) was the fifth pharaoh of the eighteenth dynasty of Ancient Egypt...

. His mother, Ah-hotep, was a member of the royal harem; the name of the mother has survived on a piece of limestone found in the temple of Thutmosis III at Qurna

Kurna

Kurna are various spelling for a group of three closely related villages located on the West Bank of the River Nile opposite the modern city of Luxor in Egypt near the Theban Hills.New Qurna was designed and built in the late 1940s and early 1950s by...

 (Excavations of Weigall, 1906). His father, Hapu, was Lecture Priest of Amun. His brother, Sa-Amun, was a scribe and 1st sealer of the god Amun. He also had a sister named Ahmose.

His wife Amenhotep bore him three sons Djehutjmes-machet, User-pechtj, and Aa-cheper-ka-ra-nefer(who was High Priest at the Mortuary Temple of Thutmosis II, lector priest) and 4 daughters Henut, Henut-nefert (a singer of Amun), Sen-seneb, and Ta-em-resefu (also a singer of Amun).

Hapuseneb served as High Priest during Year 2 to Year 16 of Hatshepsut.