Hermann Mucke (bioscientist)
Encyclopedia
Hermann A. M. Mucke is an Austrian
bioscientist with a peer-review publishing record in the fields of molecular biology
, neuropsychiatry
, cardiology
and ophthalmology
, mostly from the perspective of drug development
. He is also a management consultant
and entrepreneur working and publishing in biopharmaceutical strategic knowledge management
, intellectual property
management, and life science technology assessment
.
where he obtained his master and Ph.D. degrees in biochemistry. This earliest plant molecular biology phase of Mucke's work concerned the characterization and partial sequencing of the Cyanophora cyanelle genome, believed to resemble early stages of chloroplast evolution according to the endosymbiotic theory
.
assay for the detection of antibodies to the human immunodeficiency virus
in human body fluids which was approved under the name Fluorognost(TM) HIV-1 by the U.S. FDA approval on February 5, 1992. A human T-lymphotropic virus
antibody test, developed by Mucke's team but never marketed, served to demonstrate the first evidence of retrovirus-like serological reactivity in patients with the myelodysplastic syndrome
, a finding that meanwhile has been corroborated on the genomic level.
In 1994 Mucke developed a new research focus in neuropsychiatry, initially with a focus on Alzheimer's disease
and related neurodegenerative diseases. He directed an R&D program for galantamine
derivatives. Soon thereafter he began to cooperate with various pharmaceutical intelligence providers and publishers in the United States and the United Kingdom, both as an author and as a contributing editor.
took note of the fact. Since this time he has been an independent scientific advisor to life science companies and a prolific author of market and technology reports. He continues to publish his own original scientific research and commissioned reviews both in commercial and open access
peer-review journals. His most recent papers demonstrate a systematic utilization of patent
documents as a source of information in science, technology, and market research in the fields of ophthalmology
, renal and cardiorespiratory medicine, especially pulmonary hypertension
, and endothelin receptor antagonist
s.
By 2009 Hermann Mucke had authored or co-authored about 50 peer reviewed original research papers and invited reviews, in addition to dozens of drug evaluations. He is also a coinventor on several patent families which concern themselves with the pharmacotherapy of alcohol abuse
, nicotine dependence
, and depression.
Hermann Mucke is Patent Editor at the Thomson Reuters
journal, Current Opinion in Investigational Drugs
and an advisor to the Antiviral Spot of Excellence Vienna (ASPEX). He is frequently interviewed by media covering the pharmaceutical industry, mostly on issues concerning the streamlining of drug development through optimization of clinical trials, new approaches to the clinical trial process, or medical imaging.
Austrians
Austrians are a nation and ethnic group, consisting of the population of the Republic of Austria and its historical predecessor states who share a common Austrian culture and Austrian descent....
bioscientist with a peer-review publishing record in the fields of molecular biology
Molecular biology
Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...
, neuropsychiatry
Neuropsychiatry
Neuropsychiatry is the branch of medicine dealing with mental disorders attributable to diseases of the nervous system. It preceded the current disciplines of psychiatry and neurology, in as much as psychiatrists and neurologists had a common training....
, cardiology
Cardiology
Cardiology is a medical specialty dealing with disorders of the heart . The field includes diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart disease and electrophysiology...
and ophthalmology
Ophthalmology
Ophthalmology is the branch of medicine that deals with the anatomy, physiology and diseases of the eye. An ophthalmologist is a specialist in medical and surgical eye problems...
, mostly from the perspective of drug development
Drug development
Drug development is a blanket term used to define the process of bringing a new drug to the market once a lead compound has been identified through the process of drug discovery...
. He is also a management consultant
Management consulting
Management consulting indicates both the industry and practice of helping organizations improve their performance primarily through the analysis of existing organizational problems and development of plans for improvement....
and entrepreneur working and publishing in biopharmaceutical strategic knowledge management
Knowledge management
Knowledge management comprises a range of strategies and practices used in an organization to identify, create, represent, distribute, and enable adoption of insights and experiences...
, intellectual property
Intellectual property
Intellectual property is a term referring to a number of distinct types of creations of the mind for which a set of exclusive rights are recognized—and the corresponding fields of law...
management, and life science technology assessment
Technology assessment
Technology assessment Technology assessment Technology assessment (TA, German Tenteractive, and communicative process that aims to contribute to the formation of public and political opinion on societal aspects of science and technology.- General description :...
.
Academic career
Hermann Mucke attended the University of ViennaUniversity of Vienna
The University of Vienna is a public university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world...
where he obtained his master and Ph.D. degrees in biochemistry. This earliest plant molecular biology phase of Mucke's work concerned the characterization and partial sequencing of the Cyanophora cyanelle genome, believed to resemble early stages of chloroplast evolution according to the endosymbiotic theory
Endosymbiotic theory
The endosymbiotic theory concerns the mitochondria, plastids , and possibly other organelles of eukaryotic cells. According to this theory, certain organelles originated as free-living bacteria that were taken inside another cell as endosymbionts...
.
Industry research executive
After leaving the university Mucke became executive director of research and development at an Austrian pharmaceutical company. He developed an indirect immunofluorescenceImmunofluorescence
Immunofluorescence is a technique used for light microscopy with a fluorescence microscope and is used primarily on biological samples. This technique uses the specificity of antibodies to their antigen to target fluorescent dyes to specific biomolecule targets within a cell, and therefore allows...
assay for the detection of antibodies to the human immunodeficiency virus
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...
in human body fluids which was approved under the name Fluorognost(TM) HIV-1 by the U.S. FDA approval on February 5, 1992. A human T-lymphotropic virus
Human T-lymphotropic virus
Human T-cell Lymphotropic Virus Type 1 , also called the Adult T-cell lymphoma virus type 1, a virus that has been seriously implicated in several kinds of diseases including HTLV-I-associated myelopathy, Strongyloides stercoralis hyper-infection, and a virus cancer link for leukemia...
antibody test, developed by Mucke's team but never marketed, served to demonstrate the first evidence of retrovirus-like serological reactivity in patients with the myelodysplastic syndrome
Myelodysplastic syndrome
The myelodysplastic syndromes are a diverse collection of hematological medical conditions that involve ineffective production of the myeloid class of blood cells....
, a finding that meanwhile has been corroborated on the genomic level.
In 1994 Mucke developed a new research focus in neuropsychiatry, initially with a focus on Alzheimer's disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
and related neurodegenerative diseases. He directed an R&D program for galantamine
Galantamine
Galantamine is used for the treatment of mild to moderate Alzheimer’s disease and various other memory impairments, in particular those of vascular origin...
derivatives. Soon thereafter he began to cooperate with various pharmaceutical intelligence providers and publishers in the United States and the United Kingdom, both as an author and as a contributing editor.
Industry advisor and publisher
When in 2000 Mucke resigned his executive function in the pharmaceutical industry to set up his own consulting enterprise, the financial newspaper WirtschaftsBlattWirtschaftsBlatt
WirtschaftsBlatt is the only daily Austrian financial newspaper. Since 25 January 2007 the online version of the newspaper is available....
took note of the fact. Since this time he has been an independent scientific advisor to life science companies and a prolific author of market and technology reports. He continues to publish his own original scientific research and commissioned reviews both in commercial and open access
Open access journal
Open access journals are scholarly journals that are available online to the reader "without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself." Some are subsidized, and some require payment on behalf of the author.Subsidized journals...
peer-review journals. His most recent papers demonstrate a systematic utilization of patent
Patent
A patent is a form of intellectual property. It consists of a set of exclusive rights granted by a sovereign state to an inventor or their assignee for a limited period of time in exchange for the public disclosure of an invention....
documents as a source of information in science, technology, and market research in the fields of ophthalmology
Ophthalmology
Ophthalmology is the branch of medicine that deals with the anatomy, physiology and diseases of the eye. An ophthalmologist is a specialist in medical and surgical eye problems...
, renal and cardiorespiratory medicine, especially pulmonary hypertension
Pulmonary hypertension
In medicine, pulmonary hypertension is an increase in blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, together known as the lung vasculature, leading to shortness of breath, dizziness, fainting, and other symptoms, all of which are exacerbated by exertion...
, and endothelin receptor antagonist
Endothelin receptor antagonist
A endothelin receptor antagonist is a drug that blocks endothelin receptors.Three main kinds of ERAs exist:* selective ETA receptor antagonists , which affect endothelin A receptors....
s.
By 2009 Hermann Mucke had authored or co-authored about 50 peer reviewed original research papers and invited reviews, in addition to dozens of drug evaluations. He is also a coinventor on several patent families which concern themselves with the pharmacotherapy of alcohol abuse
Alcohol abuse
Alcohol abuse, as described in the DSM-IV, is a psychiatric diagnosis describing the recurring use of alcoholic beverages despite negative consequences. Alcohol abuse eventually progresses to alcoholism, a condition in which an individual becomes dependent on alcoholic beverages in order to avoid...
, nicotine dependence
Nicotine
Nicotine is an alkaloid found in the nightshade family of plants that constitutes approximately 0.6–3.0% of the dry weight of tobacco, with biosynthesis taking place in the roots and accumulation occurring in the leaves...
, and depression.
Hermann Mucke is Patent Editor at the Thomson Reuters
Thomson Reuters
Thomson Reuters Corporation is a provider of information for the world's businesses and professionals and is created by the Thomson Corporation's purchase of Reuters Group on 17 April 2008. Thomson Reuters is headquartered at 3 Times Square, New York City, USA...
journal, Current Opinion in Investigational Drugs
and an advisor to the Antiviral Spot of Excellence Vienna (ASPEX). He is frequently interviewed by media covering the pharmaceutical industry, mostly on issues concerning the streamlining of drug development through optimization of clinical trials, new approaches to the clinical trial process, or medical imaging.
External links
- Peer-reviewed papers by Hermann A.M. Mucke in PubMed Dynamic query
- Papers by Hermann A. M. Mucke in Google Scholar Dynamic query
- Literature-based profile for Hermann A.M. Mucke at BiomedExpertsBiomedExpertsBiomedExperts is a publication-based scientific social network that allows researchers to collaborate virtually, in order to increase biomedical research. It involves more than 3,500 institutions in more than 190 countries.-External links:*...
Dynamic query