Hideyo Noguchi
Encyclopedia
, also known as , was a prominent Japanese bacteriologist who discovered the agent of syphilis
Syphilis
Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum subspecies pallidum. The primary route of transmission is through sexual contact; however, it may also be transmitted from mother to fetus during pregnancy or at birth, resulting in congenital syphilis...

 as the cause of progressive paralytic disease in 1911.

Early life

Noguchi Hideyo was born in Inawashiro
Inawashiro, Fukushima
is a town located in Yama District, Fukushima, Japan. Inawashiro rests on the shores of Lake Inawashiro, one of the largest lakes in Japan. During the Edo period, it was part of the Aizu domain, and was the home of Aizu's secondary castle town...

, Fukushima prefecture
Fukushima Prefecture
is a prefecture of Japan located in the Tōhoku region on the island of Honshu. The capital is the city of Fukushima.-History:Until the Meiji Restoration, the area of Fukushima prefecture was known as Mutsu Province....

 in 1876. When he was one and a half years old he fell down into a fireplace and suffered a burn injury on his left hand. There was no doctor in the small village, but one of the men examined the boy. "The fingers of the left hand are mostly gone," he said, "and the left arm and the left foot and the right hand are burned; I know not how badly."

In 1883 he entered Mitsuwa elementary school. Thanks to generous contributions from his teacher Kobayashi and his friends, he was able to receive surgery on his badly burned left hand. He recovered about 70% mobility and functionality in his left hand through the operation.

Noguchi decided to become a doctor to help those in need. He apprenticed himself to , the same doctor who had performed the surgery on his hand. He entered Saisei Gakusha that later became Nippon Medical School
Nippon Medical School
is a private university in Sendagi, Bunkyo-ku, Tokyo, Japan. In 1876, Tai Hasegawa established a medical school in Tokyo. At that time, the Japanese government and the ministry of education had never permitted any medical schools except The University of Tokyo School of Medicine...

. He passed the examinations to practice medicine when he was twenty years old in 1897. He showed signs of great talent and was supported in his studies by Dr. Morinosuke Chiwaki
Morinosuke Chiwaki
was a dentist and the Chairman of the Japan Dental Association.He was a one of founders at Takayama dental school .He was known as Hideyo Noguchi's patron.-External links:*...

. In 1898, he changed his first name to Hideyo after reading a novel about a doctor who had the same name - Seisaku - as him. The doctor in the novel was intelligent like Noguchi, but became lazy and ruined his life.

Career

In 1900 Noguchi moved to the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...

, where he obtained a job as a research assistant with Dr. Simon Flexner
Simon Flexner
Simon Flexner, M.D. was a physician, scientist, administrator, and professor of experimental pathology at the University of Pennsylvania . He was the first director of the Rockefeller Institute for Medical Research and a trustee of the Rockefeller Foundation...

 at the University of Pennsylvania
University of Pennsylvania
The University of Pennsylvania is a private, Ivy League university located in Philadelphia, Pennsylvania, United States. Penn is the fourth-oldest institution of higher education in the United States,Penn is the fourth-oldest using the founding dates claimed by each institution...

 and later at the Rockefeller Institute of Medical Research. He thrived in this environment. At this time his work concerned poisonous snakes. In part, his move was motivated by difficulties in obtaining a medical position in Japan, as prospective employers were concerned about the impact the hand deformity would have on potential patients. In a research setting, this handicap became a non-issue. He and his peers learned from their work and from each other. In this period, a fellow research assistant in Flexner's lab was Frenchman Alexis Carrel
Alexis Carrel
Alexis Carrel was a French surgeon and biologist who was awarded the Nobel Prize in Physiology or Medicine in 1912 for pioneering vascular suturing techniques. He invented the first perfusion pump with Charles A. Lindbergh opening the way to organ transplantation...

, who would go on to win a Nobel Prize
Nobel Prize
The Nobel Prizes are annual international awards bestowed by Scandinavian committees in recognition of cultural and scientific advances. The will of the Swedish chemist Alfred Nobel, the inventor of dynamite, established the prizes in 1895...

 in 1912; and Noguchi's work would later attract the Prize committee's scrutiny. The Nobel Foundation archives have been only recently opened for public inspection; and what was once only speculation is now confirmed. He was nominated for the Nobel Prize in Physiology or Medicine
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the field of life science and medicine. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will...

 in 1913-1915, 1920, 1921 and 1924-1927.

While working at the Rockefeller Institute of Medical Research in 1913, he demonstrated the presence of Treponema pallidum
Treponema pallidum
Treponema pallidum is a species of spirochaete bacterium with subspecies that cause treponemal diseases such as syphilis, bejel, pinta and yaws. The treponemes have a cytoplasmic and outer membrane...

(syphilitic spirochete) in the brain of a progressive paralysis patient, proving that the spirochete was the cause of the disease. Dr. Noguchi's name is remembered in the binomial attached to another spirochete, Leptospira noguchii.

In 1918, Noguchi traveled extensively in Central America
Central America
Central America is the central geographic region of the Americas. It is the southernmost, isthmian portion of the North American continent, which connects with South America on the southeast. When considered part of the unified continental model, it is considered a subcontinent...

 and South America
South America
South America is a continent situated in the Western Hemisphere, mostly in the Southern Hemisphere, with a relatively small portion in the Northern Hemisphere. The continent is also considered a subcontinent of the Americas. It is bordered on the west by the Pacific Ocean and on the north and east...

 to do research for a vaccine
Vaccine
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...

 for yellow fever
Yellow fever
Yellow fever is an acute viral hemorrhagic disease. The virus is a 40 to 50 nm enveloped RNA virus with positive sense of the Flaviviridae family....

, and to research Oroya fever, poliomyelitis
Poliomyelitis
Poliomyelitis, often called polio or infantile paralysis, is an acute viral infectious disease spread from person to person, primarily via the fecal-oral route...

 and trachoma
Trachoma
Trachoma is an infectious disease causing a characteristic roughening of the inner surface of the eyelids. Also called granular conjunctivitis and Egyptian ophthalmia, it is the leading cause of infectious blindness in the world...

. While in Ecuador
Ecuador
Ecuador , officially the Republic of Ecuador is a representative democratic republic in South America, bordered by Colombia on the north, Peru on the east and south, and by the Pacific Ocean to the west. It is one of only two countries in South America, along with Chile, that do not have a border...

, he received a commission as a colonel
Colonel
Colonel , abbreviated Col or COL, is a military rank of a senior commissioned officer. It or a corresponding rank exists in most armies and in many air forces; the naval equivalent rank is generally "Captain". It is also used in some police forces and other paramilitary rank structures...

 in the Ecuadoran Army.

Death

In 1928, Noguchi traveled to Africa
Africa
Africa is the world's second largest and second most populous continent, after Asia. At about 30.2 million km² including adjacent islands, it covers 6% of the Earth's total surface area and 20.4% of the total land area...

 to confirm his findings. The purpose of this field work was to test the hypothesis that yellow fever was caused by spirochaete
Spirochaete
Spirochaetes belong to a phylum of distinctive Gram-negative bacteria, which have long, helically coiled cells...

 bacteria
Bacteria
Bacteria are a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals...

 instead of a virus
Virus
A virus is a small infectious agent that can replicate only inside the living cells of organisms. Viruses infect all types of organisms, from animals and plants to bacteria and archaea...

. While working in Accra
Accra
Accra is the capital and largest city of Ghana, with an urban population of 1,658,937 according to the 2000 census. Accra is also the capital of the Greater Accra Region and of the Accra Metropolitan District, with which it is coterminous...

, Gold Coast
Gold Coast (British colony)
The Gold Coast was a British colony on the Gulf of Guinea in west Africa that became the independent nation of Ghana in 1957.-Overview:The first Europeans to arrive at the coast were the Portuguese in 1471. They encountered a variety of African kingdoms, some of which controlled substantial...

 (modern-day Ghana
Ghana
Ghana , officially the Republic of Ghana, is a country located in West Africa. It is bordered by Côte d'Ivoire to the west, Burkina Faso to the north, Togo to the east, and the Gulf of Guinea to the south...

) he died from yellow fever
Yellow fever
Yellow fever is an acute viral hemorrhagic disease. The virus is a 40 to 50 nm enveloped RNA virus with positive sense of the Flaviviridae family....

 on May 21, 1928, his last words being "I don't understand."

Postscript

While Noguchi was famous during his lifetime, later research was not able to reproduce many of his claims including having discovered the causes of polio, rabies, syphilis, trachoma, and yellow fever.

Selected works

Washington, D.C.: Carnegie Institution. [OCLC 2377892]
Washington, D.C.: Carnegie Institution. [OCLC 14796920]
Philadelphia: J. B. Lippincott
Lippincott Williams & Wilkins
Lippincott Williams & Wilkins is an academic and professional medical publisher owned by Wolters Kluwer group. It publishes textbooks, various electronic media, and over 275 journals and newsletters in the health-care field. Publications are aimed at physicians, nurses, clinicians, and students...

. [OCLC 3201239]
New York: P. B. Hoeber
Harper & Brothers
Harper is an American publishing house, the flagship imprint of global publisher HarperCollins.-History:James Harper and his brother John, printers by training, started their book publishing business J. & J. Harper in 1817. Their two brothers, Joseph Wesley Harper and Fletcher Harper, joined them...

. [OCLC 14783533]

Honors during Noguchi's lifetime

Noguchi was honored with both Japanese and foreign decorations. He received honorary degrees from a number of universities.

He was self-effacing in his public life, and he often referred to himself with naive objectiveness, as "funny Noguchi;" but those who knew him well reported that he "gloated in honors." When Noguchi was awarded an honorary doctorate at Yale, William Lyon Phelps
William Lyon Phelps
William Lyon Phelps was an American author, critic and scholar. He taught the first American university course on the modern novel. He was a well-known speaker who drew large crowds...

 observed that the Kings of Spain, Denmark and Sweden had conferred awards, but "perhaps he appreciates even more than royal honors the admiration and the gratitude of the people."
  • Kyoto Imperial University - Doctor of Medicine
    Doctor of Medicine
    Doctor of Medicine is a doctoral degree for physicians. The degree is granted by medical schools...

    , 1909.
  • Order of Dannebrog, 1913 (Denmark
    Denmark
    Denmark is a Scandinavian country in Northern Europe. The countries of Denmark and Greenland, as well as the Faroe Islands, constitute the Kingdom of Denmark . It is the southernmost of the Nordic countries, southwest of Sweden and south of Norway, and bordered to the south by Germany. Denmark...

    ).
  • Order of Isabella the Catholic, 1913 (Spain
    Spain
    Spain , officially the Kingdom of Spain languages]] under the European Charter for Regional or Minority Languages. In each of these, Spain's official name is as follows:;;;;;;), is a country and member state of the European Union located in southwestern Europe on the Iberian Peninsula...

    ).
  • Order of the Polar Star
    Order of the Polar Star
    The Order of the Polar Star is a Swedish order of chivalry created by King Frederick I of Sweden on 23 February 1748, together with the Order of the Sword and the Order of the Seraphim....

    , 1914 (Sweden
    Sweden
    Sweden , officially the Kingdom of Sweden , is a Nordic country on the Scandinavian Peninsula in Northern Europe. Sweden borders with Norway and Finland and is connected to Denmark by a bridge-tunnel across the Öresund....

    ).
  • Tokyo Imperial University - Doctor of Science
    Doctor of Science
    Doctor of Science , usually abbreviated Sc.D., D.Sc., S.D. or Dr.Sc., is an academic research degree awarded in a number of countries throughout the world. In some countries Doctor of Science is the name used for the standard doctorate in the sciences, elsewhere the Sc.D...

    , 1914.
  • Order of the Rising Sun, Gold Rays with Rosette
    Order of the Rising Sun
    The is a Japanese order, established in 1875 by Emperor Meiji of Japan. The Order was the first national decoration awarded by the Japanese Government, created on April 10, 1875 by decree of the Council of State. The badge features rays of sunlight from the rising sun...

    , 1915.
  • Imperial Award
    Imperial Prize of the Japan Academy
    The was a prestigious honor conferred by the Imperial Academy from 1911 through 1945. The award was presented to non-members in recognition of their academic theses, books, and achievements....

    , Imperial Academy (Japan) - 1915.
  • Central University of Ecuador
    Central University of Ecuador
    The Central University of Ecuador is a national university located in Quito, Ecuador. It is the oldest university in Ecuador, and one of the oldest in the Americas...

    , 1919 - (Ecuador
    Ecuador
    Ecuador , officially the Republic of Ecuador is a representative democratic republic in South America, bordered by Colombia on the north, Peru on the east and south, and by the Pacific Ocean to the west. It is one of only two countries in South America, along with Chile, that do not have a border...

    ).
  • National University of San Marcos
    National University of San Marcos
    The National University of San Marcos is the most important and respected higher-education institution in Peru. Its main campus, the University City, is located in Lima...

    , 1920 - (Peru)
  • University of Guayaquil
    University of Guayaquil
    The University of Guayaquil , known colloquially as the Estatal, is a public university located in Guayaquil, Guayas Province, Ecuador. It is the oldest university in the city and has the largest student body. It also operates six extension universities throughout the country.-External links:* ,...

    , 1919 - Ecuador
    Ecuador
    Ecuador , officially the Republic of Ecuador is a representative democratic republic in South America, bordered by Colombia on the north, Peru on the east and south, and by the Pacific Ocean to the west. It is one of only two countries in South America, along with Chile, that do not have a border...

    .
  • Yale University
    Yale University
    Yale University is a private, Ivy League university located in New Haven, Connecticut, United States. Founded in 1701 in the Colony of Connecticut, the university is the third-oldest institution of higher education in the United States...

    , 1921 - (US).

Posthumous honors

Noguchi's remains were returned to the United States and buried in New York City's Woodlawn Cemetery.

In 1928, the Japanese government awarded Noguchi the Order of the Rising Sun, Gold and Silver Star
Order of the Rising Sun
The is a Japanese order, established in 1875 by Emperor Meiji of Japan. The Order was the first national decoration awarded by the Japanese Government, created on April 10, 1875 by decree of the Council of State. The badge features rays of sunlight from the rising sun...

, which represents the second highest of eight classes associated with the award.

In 1979, the Noguchi Memorial Institute of Medical Research (NMIMR) was founded with funds donated by the Japanese government. The Institute is located at the University of Ghana
University of Ghana
The University of Ghana is the oldest and largest of the thirteen Ghanaian universities and tertiary institutions. It is one of the best universities in Africa and by far the most prestigious in West Africa...

 in Legon, a suburb north of Accra
Accra
Accra is the capital and largest city of Ghana, with an urban population of 1,658,937 according to the 2000 census. Accra is also the capital of the Greater Accra Region and of the Accra Metropolitan District, with which it is coterminous...

.

Dr. Noguchi's portrait has been printed on Japanese 1000 yen banknotes
Banknotes of the Japanese yen
The banknotes of the Japanese yen are part of the physical form of Japan's currency. The issuance of the yen banknotes began in 1872, two years after the currency was introduced. Throughout its history, the denominations have ranged from 0.05 yen to 10,000 yen.- Before World War II :In 1872, the...

 since 2004. In addition, the house where he was born and brought up is preserved and is part of a museum to his life and its achievements near Inawashiro.

Noguchi's name is honored at the Centro de Investigaciones Regionales Dr. Hideyo Noguchi at the Universidad Autónoma de Yucatán
Universidad Autónoma de Yucatán
The Universidad Autónoma de Yucatán , or UADY, is an autonomous public university in the state of Yucatán, Mexico, with its central campuses located in the state capital of Mérida...

.

Hideyo Noguchi Africa Prize

The Japanese Government established the Hideyo Noguchi Africa Prize
Hideyo Noguchi Africa Prize
The honors men and women "with outstanding achievements in the fields of medical research and medical services to combat infectious and other diseases in Africa, thus contributing to the health and welfare of the African people and of all humankind." The prize, officially named "The Prize in...

 in July 2006 as a new international medical research and services award to mark the official visit by Prime Minister Jun'ichirō Koizumi
Junichiro Koizumi
is a Japanese politician who served as Prime Minister of Japan from 2001 to 2006. He retired from politics when his term in parliament ended.Widely seen as a maverick leader of the Liberal Democratic Party , he became known as an economic reformer, focusing on Japan's government debt and the...

 to Africa in May 2006 and the 80th anniversary of Dr. Noguchi’s death. The Prize aims to honor individuals with outstanding achievements in combating various infectious diseases in Africa or in establishing innovative medical service systems. The presentation ceremony and laureate lectures coincided with the Fourth Tokyo International Conference on African Development
Tokyo International Conference on African Development
is a conference held every five years in Tokyo, Japan, with the objective "to promote high-level policy dialogue between African leaders and development partners." Japan is a co-host of these conferences. Other co-organizers of TICAD are the United Nations Office of the Special Advisor on Africa...

 (TICAD) in late April 2008. This year's conference venue was moved from Tokyo to Yokohama as another way of honoring the man after whom the prize was named. In 1899, Dr. Noguchi worked at the Yokohama Port Quarantine Office as an assistant quarantine doctor.

The first awards of this international prize—consisting of a citation, a medal and an honorarium of 100 million yen (US$1,186,000) are only intended to be the first in a continuing series; and subsequently the Prize is expected to be awarded every five years. The prize as been made possible through a combination of government funding and private donations.

Human experimentation

In 1911 and 1912 at the Rockefeller Institute in New York City, Noguchi was working to develop a syphilis skin test similar to the tuberculin skin test. The subjects were recruited from clinics and hospitals in New York. In the experiment, Noguchi injected an extract of syphilis under the subjects' upper arm skin. Skin reactions varied among healthy subjects and syphilis patients by the disease's stage and its treatment. Of the 571 subjects, 315 had syphilis. The remaining subjects were "controls" who did not have syphilis and were orphans or hospital patients. The hospital patients had nonsyphilitic diseases, such as malaria, leprosy, tuberculosis, and pneumonia. Finally, of the controls, were normal individuals, mostly children between the ages of 2 and 18 years. Critics at the time noted that Noguchi violated the rights of orphans and hospital patients. He was later sued by the parents of some of the child subjects, who allegedly contracted syphilis as a result of his experiments.

See also

  • List of prizes, medals, and awards‎
  • Max Theiler
    Max Theiler
    Max Theiler was a South African/American virologist. He was awarded the Nobel Prize in Physiology or Medicine in 1951 for developing a vaccine against yellow fever.-Career development:...

     - completed Noguchi's work, yellow fever vaccine (1926)
  • Human experimentation in the United States
    Human experimentation in the United States
    There have been numerous experiments performed on human test subjects in the United States that have been considered unethical, and were often performed illegally, without the knowledge, consent, or informed consent of the test subjects....


External links

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