Higoumenakis sign
Encyclopedia
Higouménakis' sign is a unilateral enlargement of the sternoclavicular portion of the clavicle
Clavicle
In human anatomy, the clavicle or collar bone is a long bone of short length that serves as a strut between the scapula and the sternum. It is the only long bone in body that lies horizontally...

, seen in congenital syphilis
Congenital syphilis
Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a mother with secondary syphilis. Untreated syphilis results in a high risk of a bad outcome of pregnancy, including mulberry molars in the fetus. Syphilis can cause miscarriages, premature births,...

. It's an end result of neonatal periostitis
Periostitis
Periostitis, also known as periostalgia, is a medical condition caused by inflammation of the periosteum, a layer of connective tissue that surrounds bone...

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The sign was first described by George K. Higoumenakis in 1927 in the Greek periodical Proceedings of the Medical Society of Athens (Πρακτικά Ιατρικής Εταιρείας Αθηνών). He subsequently published the description of the sign in a German article, making the sign more known among dermatologists. Thus, the sign was named after George Higoumenakis.

George Higoumenakis (1895–1983) was a Greek dermatologist born in Iraklion of Crete
Crete
Crete is the largest and most populous of the Greek islands, the fifth largest island in the Mediterranean Sea, and one of the thirteen administrative regions of Greece. It forms a significant part of the economy and cultural heritage of Greece while retaining its own local cultural traits...

 (Greece). He studied medicine at the Medical School of the National University of Athens. He then chose to become a dermatologist and went to France to fulfil his desire. He was a student of Gaston Milian, a famous syphilologist, at the Hospital St. Louis.

He returned to Greece in 1924, became a member of the Medical Society of Athens and began practicing medicine privately. He aspired to pursue an academic career as well in the National University of Athens, but this never occurred, possibly due to conflicts with professors at the Medical School of Athens. Nevertheless, these setbacks did not put him down. He became a director of the Department of Dermatology at the hospital "Evaggelismos" and practiced medicine successfully until the 1940s. Although he continued practicing medicine after as well, he got involved with politics and managed to become in 1965 a Member of the Greek Parliament and Minister of Hygiene.

Konstanin G. Higoumenakis is his son. He is a dermatologist and a retired assistant professor of Dermatology from the National and Kapodistrian University of Athens
National and Kapodistrian University of Athens
The National and Kapodistrian University of Athens , usually referred to simply as the University of Athens, is the oldest university in Southeast Europe and has been in continuous operation since its establishment in 1837. Today, it is the second-largest institution of higher learning in Greece,...

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