Dr. Ignaz Semmelweis

Ignaz Semmelweis

Ignaz Philipp Semmelweis was a Hungarian physician now known as an early pioneer of antiseptic procedures. Described as the "savior of mothers", Semmelweis discovered that the incidence of puerperal fever could be drastically cut by the use of hand disinfection in obstetrical clinics...

 worked at the Vienna General Hospital

Vienna General Hospital

The Vienna General Hospital is the University medical center of the city of Vienna, Austria. The AKH is the largest hospital of Austria and Europe, the second largest hospital in the world, and at 85-m high is one of the tallest hospital buildings in the world...

's maternity clinic on a 3-year contract from 1846-1849. There, as elsewhere in European and North American hospitals, puerperal fever

Puerperal fever

Puerperal fever or childbed fever, is a bacterial infection contracted by women during childbirth or miscarriage. It can develop into puerperal sepsis, which is a serious form of septicaemia. If untreated, it is often fatal....

, or childbed fever, was rampant, sometimes climbing to 40 percent of admitted patients. He was disturbed by these mortality rates, and eventually developed a theory of infection, in which he theorized that decaying matter on the hands of doctors, who had recently conducted autopsies, was brought into contact with the genitals of birthgiving women during the medical examinations at the maternity clinic. He proposed a radical hand washing theory using chlorinated lime, now a known disinfectant.

At the time however, the germ theory of infection had not been developed and Semmelweis' ideas ran contrary to key medical beliefs and practices at the time. His ideas were rejected and ridiculed. Quite unusually, his contract was not renewed, effectively expelling him from the medical community in Vienna. He died as an outcast in a mental institution.

Puerperal fever - a modern disease

An 1841 account of epidemic childbed fever states that insofar as existing historical documents permit one to judge, childbed fever is a modern disease. The cases reported by Hippocrates

Hippocrates

Hippocrates of Cos or Hippokrates of Kos was an ancient Greek physician of the Age of Pericles , and is considered one of the most outstanding figures in the history of medicine...

 that are generally identified as such are not puerperal fever. There are only examples of bilious fever, then common, which among maternity patients was no different from its appearance among non-maternity patients or men; Hippocrates himself never identified it as a separate and distinguishable disease.

Hospital Hôtel-Dieu de Paris

We encounter the first, as yet unclear indication of childbed fever in the second half of the 17th century at the Hôtel-Dieu

Hôtel-Dieu de Paris

The Hôtel-Dieu de Paris is regarded as the oldest hospital in the city of Paris, France, and is the most central of the Assistance publique - hôpitaux de Paris hospitals. The hospital is linked to the Faculté de Médecine Paris-Descartes...

 in Paris. Phillipe Peu relates that mortality among the newly delivered was very great and greater in certain seasons than others. The year 1664 was particularly devastating.

Another account states that the lower abdominal infection, la fièvre puerpérale, had raged every winter since 1774 among the maternity patients of the Hôtel-Dieu, and that often as many as 7 of every 12 patients suffered from it.

The maternity clinic at Würzburg

For the relatively small maternity clinic at Würzburg

Würzburg

Würzburg is a city in the region of Franconia which lies in the northern tip of Bavaria, Germany. Located at the Main River, it is the capital of the Regierungsbezirk Lower Franconia. The regional dialect is Franconian....

 in Germany, Franz Kiwisch von Rotterau

Franz Kiwisch von Rotterau

Franz Kiwisch von Rotterau was Professor of Obstetrics at the University of Würzburg and later at the University of Prague. He was one of Semmelweis's principal opponents. In Würzburg he was succeeded by Friedrich Wilhelm Scanzoni von Lichtenfels.A native of Klattau in Bohemia, he earned his...

 reported 27 deaths from 102 patients (26.5 %) cared for during one year, much higher than the Viennese hospital. Semmelweis explained this from the need in small hospitals to use every patient as teaching material. In contrast, "in Vienna there is such an excess of teaching material that hundreds of individuals are not used for teaching and thus are not infected".

Inconsistencies in data

There are various inconsistencies in the datasets reported by Semmelweis and provided below. Inconsistencies exist for instance in reported yearly rates, and monthly rates (if aggregated to yearly basis). One of the causes may be that Semmelweis used different sources. He points out several times that actual mortality rates were higher than reported ones, because during childbed fever epidemics, the maternity ward was overwhelmed with dying women, who were then transferred to the general hospital, and therefore not registered at the maternity ward, when dying. Some women were also released from the maternity ward, either healthy or not so healthy, only to be readmitted to the general hospital when symptoms appeared or worsened. See also a similar underreporting practice at the Charité in Berlin, Joseph Hermann Schmidt

Joseph Hermann Schmidt

Joseph Hermann Schmidt was professor of Obstetrics in Berlin, and official of the Prussian cultural ministry.In 1834 he became head of the Paderborn general hospital and eventually also of the Paderborn maternity clinic. He wrote a textbook of obstetrics widely used in Prussia...

.

There were two maternity clinics at the Vienna General Hospital

Vienna General Hospital

The Vienna General Hospital is the University medical center of the city of Vienna, Austria. The AKH is the largest hospital of Austria and Europe, the second largest hospital in the world, and at 85-m high is one of the tallest hospital buildings in the world...

. Semmelweis is not always specific, if the numbers are for both clinics, or for his own clinic only. The figures presented below are exactly as reported in (the 1983 translation by Carter of) Semmelweis' 1861 publication.

There are also at times minor arithmetical errors in his computed rates; for this reason all rates on this page are computed.

Monthly mortality rates for birthgiving women 1841-1849

The table below shows monthly incidence rates from 1841–1849, in particular the remarkable decline in mortality rates from June 1847 to February 1849, when Semmelweis' handwashing policy was implemented.

generated with :de:Wikipedia:Helferlein/VBA-Macro for EXCEL tableconversion V1.7<\hiddentext>>

Puerperal fever

Puerperal fever

Puerperal fever or childbed fever, is a bacterial infection contracted by women during childbirth or miscarriage. It can develop into puerperal sepsis, which is a serious form of septicaemia. If untreated, it is often fatal....

 mortality rates for birthgiving women at the first clinic at the Vienna General Hospital

Vienna General Hospital

The Vienna General Hospital is the University medical center of the city of Vienna, Austria. The AKH is the largest hospital of Austria and Europe, the second largest hospital in the world, and at 85-m high is one of the tallest hospital buildings in the world...

 1841-1849 reported by Semmelweis

Semmelweis

Semmelweis is surname of:* Ignaz Philipp Semmelweis* Contemporary reaction to Ignaz Semmelweis* Semmelweis reflex * Semmelweis Society, a non-profit whistleblower and advocacy group for physicians formed in 1986...

. He devised and instituted a handwashing policy by mid-May 1847. His employment was terminated March 20, 1849

Year	Month	Births	Deaths	Rate (%)	Sort restore
1841 | Jan | 254 | 37 | 14.6 | 1
| Feb | 239 | 18 | 7.5 | 2
| Mar | 277 | 12 | 4.3 | 3
| Apr | 255 | 4 | 1.6 | 4
| Maj | 255 | 2 | 0.8 | 5
| Jun | 200 | 10 | 5.0 | 6
| Jul | 190 | 16 | 8.4 | 7
| Aug | 222 | 3 | 1.4 | 8
| Sep | 213 | 4 | 1.9 | 9
| Okt | 236 | 26 | 11.0 | 10
| Nov | 235 | 53 | 22.6 | 11
| Dec | na | na | na | 12
1842 | Jan | 307 | 64 | 20.8 | 13
| Feb | 311 | 38 | 12.2 | 14
| Mar | 264 | 27 | 10.2 | 15
| Apr | 242 | 26 | 10.7 | 16
| Maj | 310 | 10 | 3.2 | 17
| Jun | 273 | 18 | 6.6 | 18
| Jul | 231 | 48 | 20.8 | 19
| Aug | 216 | 55 | 25.5 | 20
| Sep | 223 | 41 | 18.4 | 21
| Okt | 242 | 71 | 29.3 | 22
| Nov | 209 | 48 | 23.0 | 23
| Dec | 239 | 75 | 31.4 | 24
1843 | Jan | 272 | 52 | 19.1 | 25
| Feb | 263 | 42 | 16.0 | 26
| Mar | 266 | 33 | 12.4 | 27
| Apr | 285 | 34 | 11.9 | 28
| Maj | 246 | 15 | 6.1 | 29
| Jun | 196 | 8 | 4.1 | 30
| Jul | 191 | 1 | 0.5 | 31
| Aug | 193 | 3 | 1.6 | 32
| Sep | 221 | 5 | 2.3 | 33
| Okt | 250 | 44 | 17.6 | 34
| Nov | 252 | 18 | 7.1 | 35
| Dec | 236 | 19 | 8.1 | 36
1844 | Jan | 244 | 37 | 15.2 | 37
| Feb | 257 | 29 | 11.3 | 38
| Mar | 276 | 47 | 17.0 | 39
| Apr | 208 | 36 | 17.3 | 40
| Maj | 240 | 14 | 5.8 | 41
| Jun | 224 | 6 | 2.7 | 42
| Jul | 206 | 9 | 4.4 | 43
| Aug | 269 | 17 | 6.3 | 44
| Sep | 245 | 3 | 1.2 | 45
| Okt | 248 | 8 | 3.2 | 46
| Nov | 245 | 27 | 11.0 | 47
| Dec | 256 | 27 | 10.5 | 48
1845 | Jan | 303 | 23 | 7.6 | 49
| Feb | 274 | 13 | 4.7 | 50
| Mar | 292 | 13 | 4.5 | 51
| Apr | 260 | 11 | 4.2 | 52
| Maj | 296 | 13 | 4.4 | 53
| Jun | 280 | 20 | 7.1 | 54
| Jul | 245 | 15 | 6.1 | 55
| Aug | 251 | 9 | 3.6 | 56
| Sep | 237 | 25 | 10.5 | 57
| Okt | 283 | 42 | 14.8 | 58
| Nov | 265 | 29 | 10.9 | 59
| Dec | 267 | 28 | 10.5 | 60
1846 | Jan | 336 | 45 | 13.4 | 61
| Feb | 293 | 53 | 18.1 | 62
| Mar | 311 | 48 | 15.4 | 63
| Apr | 253 | 48 | 19.0 | 64
| Maj | 305 | 41 | 13.4 | 65
| Jun | 266 | 27 | 10.2 | 66
| Jul | 252 | 33 | 13.1 | 67
| Aug | 216 | 39 | 18.1 | 68
| Sep | 271 | 39 | 14.4 | 69
| Okt | 254 | 38 | 15.0 | 70
| Nov | 297 | 32 | 10.8 | 71
| Dec | 298 | 16 | 5.4 | 72
1847 | Jan | 311 | 10 | 3.2 | 73
| Feb | 312 | 6 | 1.9 | 74
| Mar | 305 | 11 | 3.6 | 75
| Apr | 312 | 57 | 18.3 | 76
| Maj | 294 | 36 | 12.2 | 77 | Handwashing policy instituted mid-May
| Jun | 268 | 6 | 2.2 | 78
| Jul | 250 | 3 | 1.2 | 79
| Aug | 264 | 5 | 1.9 | 80
| Sep | 262 | 12 | 4.6 | 81
| Okt | 278 | 11 | 4.0 | 82
| Nov | 246 | 11 | 4.5 | 83
| Dec | 273 | 8 | 2.9 | 84
1848 | Jan | 283 | 10 | 3.5 | 85 | strict controls enforced on students' negligent hand-wash
| Feb | 291 | 2 | 0.7 | 86
| Mar | 276 | 0 | 0.0 | 87
| Apr | 305 | 2 | 0.7 | 88
| Maj | 313 | 3 | 1.0 | 89
| Jun | 264 | 3 | 1.1 | 90
| Jul | 269 | 1 | 0.4 | 91
| Aug | 261 | 0 | 0.0 | 92
| Sep | 312 | 3 | 1.0 | 93
| Okt | 299 | 7 | 2.3 | 94
| Nov | 310 | 9 | 2.9 | 95
| Dec | 373 | 5 | 1.3 | 96
1849 | Jan | 403 | 9 | 2.2 | 97
| Feb | 389 | 12 | 3.1 | 98
| Mar | 406 | 20 | 4.9 | 99 | Semmelweis' employment terminated

Explanatory power of his theory of cadaverous poisoning

From his theory of decaying matter on the hands of examining physicians as a cause for childbed fever he was able to explain other features in the dataset, for instance why mortality rates were remarkably higher during winter than summer, because of increased student activity and scheduled autopsies immediately before the rounds at the maternity clinic. He writes:

The prevailing opinion is that winter is the season most conducive to outbreaks of childbed fever. This is explained by the different activities of those who visit the maternity hospital. These activities are determined by the season. After the long vacation in August and September, students resume their studies, including obstetrics, with renewed diligence. In winter the influx of students into the maternity hospital is so great that individuals must wait weeks and even months for their turn to study. In summer, during vacation, half or even two-thirds of the places are vacant. In winter, the pathological and forensic autopsies and the medical and surgical wards are visited industriously by those who also visit the maternity hospital. In summer, the diligence is noticeably less. The charming surroundings of Vienna are more attractive than the reeking morgue or the sultry wards of the hospital.

In winter the assistant of obstetrics holds practical operative exercises on cadavers before the afternoon rounds at the maternity ward at four o'clock, because in the mornings students are otherwise engaged, and following the afternoon rounds, at five o'clock, it is already too dark. In summer the heat is too oppressive before the afternoon visit, and the operative exercises are held in the evening following afternoon rounds.

He was able to explain additional features:

The assistant of the first clinic seldom visited the morgue in the months of December 1846 and January, February, and March 1847. The students followed his example. The opportunity for them to contaminate their hands with cadaverous particles was thereby greatly reduced. Restricting examinations to the minimum also reduced the opportunity for the genitals of patients to be touched by contaminated hands. For these reasons, mortality in the first clinic was reduced during these months.

I had Carl von Rokitansky

Carl Freiherr von Rokitansky

Baron Carl von Rokitansky , was a Bohemian physician, pathologist, humanist philosopher and liberal politician.-Medical career:...

's permission to dissect all female corpses, including those not already set aside for autopsy, in order to correlate the results of my examinations with autopsies. I devoted nearly every morning before the professor's rounds in the obstetrical clinic to these studies. On 20 March 1847, I reassumed the position of assistant in the first clinic. Early that morning I conducted my gynecological studies in the morgue. I then went to the labor room and began to examine all the patients, as my predecessors and I were obliged to do, so that I could report on each patient during the professor's morning rounds. My hands, contaminated by cadaverous particles, were thereby brought into contact with the genitals of so many women in labor that in April, from 312 deliveries, there were 57 deaths (18.3 percent). Only God knows the number of patients who went prematurely to their graves because of me. I have examined corpses to an extent equaled by few other obstetricians.

He was also able to explain why women with extended dilation

Cervical dilation

Cervical dilation is the opening of the cervix, the entrance to the uterus, during childbirth, miscarriage, induced abortion, or gynecological surgery...

 invariably died: "Infection occurs most often during dilation. [...] ..it is frequently necessary to penetrate the uterus

Uterus

The uterus or womb is a major female hormone-responsive reproductive sex organ of most mammals including humans. One end, the cervix, opens into the vagina, while the other is connected to one or both fallopian tubes, depending on the species...

 in manual examination to determine the location and position of the fetus. Thus, before chlorine washings, almost every patient whose period dilation was extended died of childbed fever."

Yearly mortality rates for birthgiving women 1833-1858 for first and second clinics

A second clinic was started in 1833 because of the large number of women being admitted to the maternity ward . Medical students and midwife students undertook their studies at both clinics. In 1841 however, these two groups were separated. Thereafter, medical students attended the first clinic only, and midwife students attended the second clinic only. Joseph Späth

Joseph Späth

Joseph Späth was Professor of Obstetrics in Vienna and from 1873 until 1886 he was director of the Second Obstetrical Clinic at the Vienna General Hospital. Ignaz Semmelweis regarded him as a principal opponent...

 was professor at the second clinic.

generated with :de:Wikipedia:Helferlein/VBA-Macro for EXCEL tableconversion V1.7<\hiddentext>>

Puerperal fever

Puerperal fever

Puerperal fever or childbed fever, is a bacterial infection contracted by women during childbirth or miscarriage. It can develop into puerperal sepsis, which is a serious form of septicaemia. If untreated, it is often fatal....

 mortality rates for birthgiving women at the first and second clinic at the Vienna General Hospital

Vienna General Hospital

The Vienna General Hospital is the University medical center of the city of Vienna, Austria. The AKH is the largest hospital of Austria and Europe, the second largest hospital in the world, and at 85-m high is one of the tallest hospital buildings in the world...

 1833-1858 reported by Semmelweis

Semmelweis

Semmelweis is surname of:* Ignaz Philipp Semmelweis* Contemporary reaction to Ignaz Semmelweis* Semmelweis reflex * Semmelweis Society, a non-profit whistleblower and advocacy group for physicians formed in 1986...

. From 1841 only midwives worked in the second clinic, after which mortality rates were markedly lower than the first clinic. Semmelweis instituted a handwashing policy in the first clinic by mid-May 1847. His employment was terminated March 20, 1849

	First clinic				Second clinic
Year | Births | Deaths | Rate (%) |   | Births | Deaths | Rate (%) | Note
1833 | 3,737 | 197 | 5.3 |   | 353 | 8 | 2.3 | Second clinic started
1834 | 2,657 | 205 | 7.7 |   | 1,744 | 150 | 8.6
1835 | 2,573 | 143 | 5.6 |   | 1,682 | 84 | 5.0
1836 | 2,677 | 200 | 7.5 |   | 1,670 | 131 | 7.8
1837 | 2,765 | 251 | 9.1 |   | 1,784 | 124 | 7.0
1838 | 2,987 | 91 | 3.0 |   | 1,779 | 88 | 4.9
1839 | 2,781 | 151 | 5.4 |   | 2,010 | 91 | 4.5
1840 | 2,889 | 267 | 9.2 |   | 2,073 | 55 | 2.7
1841 | 3,036 | 237 | 7.8 |   | 2,442 | 86 | 3.5 | Only midwives worked in the second clinic
1842 | 3,287 | 518 | 15.8 |   | 2,659 | 202 | 7.6
1843 | 3,060 | 274 | 9.0 |   | 2,739 | 164 | 6.0
1844 | 3,157 | 260 | 8.2 |   | 2,956 | 68 | 2.3
1845 | 3,492 | 241 | 6.9 |   | 3,241 | 66 | 2.0
1846 | 4,010 | 459 | 11.4 |   | 3,754 | 105 | 2.8
1847 | 3,490 | 176 | 5.0 |   | 3,306 | 32 | 1.0 | Handwashing in first clinic mid-May
1848 | 3,556 | 45 | 1.3 |   | 3,319 | 43 | 1.3
1849 | 3,858 | 103 | 2.7 |   | 3,371 | 87 | 2.6 | Semmelweis dismissed in March
1850 | 3,745 | 74 | 2.0 |   | 3,261 | 54 | 1.7
1851 | 4,194 | 75 | 1.8 |   | 3,395 | 121 | 3.6
1852 | 4,471 | 181 | 4.0 |   | 3,360 | 192 | 5.7
1853 | 4,221 | 94 | 2.2 |   | 3,480 | 67 | 1.9
1854 | 4,393 | 400 | 9.1 |   | 3,396 | 210 | 6.2
1855 | 3,659 | 198 | 5.4 |   | 2,938 | 174 | 5.9
1856 | 3,925 | 156 | 4.0 |   | 3,070 | 125 | 4.1
1857 | 4,220 | 124 | 2.9 |   | 3,795 | 83 | 2.2
1858 | 4,203 | 86 | 2.0 |   | 4,179 | 60 | 1.4

Yearly mortality rates for birthgiving women 1784-1849

Semmelweis seeks to demonstrate that the advent of pathological anatomy, and consequently the increase in autopsies, is correlated to the incidence of childbed fever. From 1789-1822 professor Johann Lucas Boër

Johann Lucas Boër

Johann Lucas Boër , originally Johann Lucas Boogers was a German medical doctor and obstetrician.-Professional life:...

 was assigned the teaching post at the maternity ward, however he left the post discouraged of what was then regarded as an enormous mortality rate. He was succeeded by professor Johann Klein

Johann Klein

Johann Klein was Professor of Obstetrics at the University of Salzburg and at the University of Vienna. Johann Baptist Chiari was his son-in-law. In Vienna, he was succeeded by professor Carl Braun in 1856....

 who reformed obstetrics to an anatomical orientation emphasizing the value of pathological autopsies. Mortality rates jump markedly.

generated with :de:Wikipedia:Helferlein/VBA-Macro for EXCEL tableconversion V1.7<\hiddentext>>

Yearly puerperal fever

Puerperal fever

Puerperal fever or childbed fever, is a bacterial infection contracted by women during childbirth or miscarriage. It can develop into puerperal sepsis, which is a serious form of septicaemia. If untreated, it is often fatal....

 mortality rates for birthgiving women at
Vienna General Hospital

Vienna General Hospital

The Vienna General Hospital is the University medical center of the city of Vienna, Austria. The AKH is the largest hospital of Austria and Europe, the second largest hospital in the world, and at 85-m high is one of the tallest hospital buildings in the world...

's maternity clinic for the period 1784-1849
reported by Semmelweis

Semmelweis

Semmelweis is surname of:* Ignaz Philipp Semmelweis* Contemporary reaction to Ignaz Semmelweis* Semmelweis reflex * Semmelweis Society, a non-profit whistleblower and advocacy group for physicians formed in 1986...

.

Year	Births	Deaths	Rate (%)	Note
1784 | 284 | 6 | 2.1 | No pathological anatomy
1785 | 899 | 13 | 1.4
1786 | 1,151 | 5 | 0.4
1787 | 1,407 | 5 | 0.4
1788 | 1,425 | 5 | 0.4
1789 | 1,246 | 7 | 0.6
1790 | 1,326 | 10 | 0.8
1791 | 1,395 | 8 | 0.6
1792 | 1,579 | 14 | 0.9
1793 | 1,684 | 44 | 2.6
1794 | 1,768 | 7 | 0.4
1795 | 1,798 | 38 | 2.1
1796 | 1,904 | 22 | 1.2
1797 | 2,012 | 5 | 0.2
1798 | 2,046 | 5 | 0.2
1799 | 2,067 | 20 | 1.0
1800 | 2,070 | 41 | 2.0
1801 | 2,106 | 17 | 0.8
1802 | 2,346 | 9 | 0.4
1803 | 2,215 | 16 | 0.7
1804 | 2,022 | 8 | 0.4
1805 | 2,112 | 9 | 0.4
1806 | 1,875 | 13 | 0.7
1807 | 925 | 6 | 0.6
1808 | 855 | 7 | 0.8
1809 | 912 | 13 | 1.4
1810 | 744 | 6 | 0.8
1811 | 1,050 | 20 | 1.9
1812 | 1,419 | 9 | 0.6
1813 | 1,945 | 21 | 1.1
1814 | 2,062 | 66 | 3.2
1815 | 2,591 | 19 | 0.7
1816 | 2,410 | 12 | 0.5
1817 | 2,735 | 25 | 0.9
1818 | 2,568 | 56 | 2.2
1819 | 3,089 | 154 | 5.0
1820 | 2,998 | 75 | 2.5
1821 | 3,294 | 55 | 1.7
1822 | 3,066 | 26 | 0.8
1823 | 2,872 | 214 | 7.5 | Pathological anatomy begins
1824 | 2,911 | 144 | 4.9
1825 | 2,594 | 229 | 8.8
1826 | 2,359 | 192 | 8.1
1827 | 2,367 | 51 | 2.2
1828 | 2,833 | 101 | 3.6
1829 | 3,012 | 140 | 4.6
1830 | 2,797 | 111 | 4.0
1831 | 3,353 | 222 | 6.6
1832 | 3,331 | 105 | 3.2
1833 | 3,737 | 197 | 5.3
1834 | 2,657 | 205 | 7.7
1835 | 2,573 | 143 | 5.6
1836 | 2,677 | 200 | 7.5
1837 | 2,765 | 251 | 9.1
1838 | 2,987 | 91 | 3.0
1839 | 2,781 | 151 | 5.4
1840 | 2,889 | 267 | 9.2
1841 | 3,036 | 237 | 7.8 | Separation of clinics
1842 | 3,287 | 518 | 15.8 | hereafter numbers refer to first clinic only
1843 | 3,060 | 274 | 9.0
1844 | 3,157 | 260 | 8.2
1845 | 3,492 | 241 | 6.9
1846 | 4,010 | 459 | 11.4
1847 | 3,490 | 176 | 5.0 | Chlorine washings begin mid-May
1848 | 3,556 | 45 | 1.3
1849 | 3,858 | 103 | 2.7 | Semmelweis Semmelweis Semmelweis is surname of:* Ignaz Philipp Semmelweis* Contemporary reaction to Ignaz Semmelweis* Semmelweis reflex * Semmelweis Society, a non-profit whistleblower and advocacy group for physicians formed in 1986...  dismissed from hospital in March

Yearly mortality rates for newborn infants 1841-1846 for first and second clinics

The mortality rate for newborn infants was also higher in the first clinic.
generated with :de:Wikipedia:Helferlein/VBA-Macro for EXCEL tableconversion V1.7<\hiddentext>>

Puerperal fever

Puerperal fever

Puerperal fever or childbed fever, is a bacterial infection contracted by women during childbirth or miscarriage. It can develop into puerperal sepsis, which is a serious form of septicaemia. If untreated, it is often fatal....

 mortality rates for newborn infants at the first and second clinic at the Vienna General Hospital

Vienna General Hospital

The Vienna General Hospital is the University medical center of the city of Vienna, Austria. The AKH is the largest hospital of Austria and Europe, the second largest hospital in the world, and at 85-m high is one of the tallest hospital buildings in the world...

 1841-1846 reported by Semmelweis

Semmelweis

Semmelweis is surname of:* Ignaz Philipp Semmelweis* Contemporary reaction to Ignaz Semmelweis* Semmelweis reflex * Semmelweis Society, a non-profit whistleblower and advocacy group for physicians formed in 1986...

.

	First clinic				Second clinic
Year | Births | Deaths | Rate (%) |   | Births | Deaths | Rate (%)
1841 | 2,813 | 177 | 6.3 |   | 2,252 | 91 | 4.0
1842 | 3,037 | 279 | 9.2 |   | 2,414 | 113 | 4.7
1843 | 2,828 | 195 | 6.9 |   | 2,570 | 130 | 5.1
1844 | 2,917 | 251 | 8.6 |   | 2,739 | 100 | 3.7
1845 | 3,201 | 260 | 8.1 |   | 3,017 | 97 | 3.2
1846 | 3,533 | 235 | 6.7 |   | 3,398 | 86 | 2.5

Yearly patient mortality rates at the Dublin Maternity Hospital 1784-1849

Semmelweis compared mortalilty rates in Vienna with maternity institutions in the United Kingdom where mortality rates were lower. He wished to show that childbed fever was related to pathological anatomy. His choice, Dublin Maternity Hospital, was like the Viennese hospital, a large teaching institution for physicians.

He argued that as a rule German and French maternity hospitals are associated with large general hospitals. Therefore their students occupy themselves in morgues, and in medical and surgical wards, as well as in maternity wards. In this way they become carriers of the decaying matter responsible for childbed fever.

Contrary hereto, maternity hospitals in the United Kingdom were independent institutions; removed from general hospitals. The students are forced to concern themselves exclusively with obstetrics, they do not carry out pathological autopsies.
generated with :de:Wikipedia:Helferlein/VBA-Macro for EXCEL tableconversion V1.7<\hiddentext>>

Yearly puerperal fever

Puerperal fever

Puerperal fever or childbed fever, is a bacterial infection contracted by women during childbirth or miscarriage. It can develop into puerperal sepsis, which is a serious form of septicaemia. If untreated, it is often fatal....

 mortality rates for birthgiving women at
Dublin Maternity Hospital for the period 1784-1849
reported by Semmelweis

Semmelweis

Semmelweis is surname of:* Ignaz Philipp Semmelweis* Contemporary reaction to Ignaz Semmelweis* Semmelweis reflex * Semmelweis Society, a non-profit whistleblower and advocacy group for physicians formed in 1986...

.

Year	Births	Deaths	Rate (%)
1784 | 1261 | 11 | 0.9
1785 | 1292 | 8 | 0.6
1786 | 1351 | 8 | 0.6
1787 | 1347 | 10 | 0.7
1788 | 1469 | 23 | 1.6
1789 | 1435 | 25 | 1.7
1790 | 1546 | 12 | 0.8
1791 | 1602 | 25 | 1.6
1792 | 1631 | 10 | 0.6
1793 | 1747 | 19 | 1.1
1794 | 1543 | 20 | 1.3
1795 | 1503 | 7 | 0.5
1796 | 1621 | 10 | 0.6
1797 | 1712 | 13 | 0.8
1798 | 1604 | 8 | 0.5
1799 | 1537 | 10 | 0.7
1800 | 1837 | 18 | 1
1801 | 1725 | 30 | 1.7
1802 | 1985 | 26 | 1.3
1803 | 2028 | 44 | 2.2
1804 | 1915 | 16 | 0.8
1805 | 2220 | 12 | 0.5
1806 | 2406 | 23 | 1
1807 | 2511 | 12 | 0.5
1808 | 2665 | 13 | 0.5
1809 | 2889 | 21 | 0.7
1810 | 2854 | 29 | 1
1811 | 2561 | 24 | 0.9
1812 | 2676 | 43 | 1.6
1813 | 2484 | 62 | 2.5
1814 | 2508 | 25 | 1
1815 | 3075 | 17 | 0.6
1816 | 3314 | 18 | 0.5
1817 | 3473 | 32 | 0.9
1818 | 3539 | 56 | 1.6
1819 | 3197 | 94 | 2.9
1820 | 2458 | 70 | 2.8
1821 | 2849 | 22 | 0.8
1822 | 2675 | 12 | 0.4
1823 | 2584 | 59 | 2.3
1824 | 2446 | 20 | 0.8
1825 | 2740 | 26 | 0.9
1826 | 2440 | 81 | 3.3
1827 | 2550 | 33 | 1.3
1828 | 2856 | 43 | 1.5
1829 | 2141 | 34 | 1.6
1830 | 2288 | 12 | 0.5
1831 | 2176 | 12 | 0.6
1832 | 2242 | 12 | 0.5
1833 | 2138 | 12 | 0.6
1834 | 2024 | 34 | 1.7
1835 | 1902 | 34 | 1.8
1836 | 1810 | 36 | 2
1837 | 1833 | 24 | 1.3
1838 | 2126 | 45 | 2.1
1839 | 1951 | 25 | 1.3
1840 | 1521 | 26 | 1.7
1841 | 2003 | 23 | 1.1
1842 | 2171 | 21 | 1
1843 | 2210 | 22 | 1
1844 | 2288 | 14 | 0.6
1845 | 1411 | 35 | 2.5
1846 | 2025 | 17 | 0.8
1847 | 1703 | 47 | 2.8
1848 | 1816 | 35 | 1.9
1849 | 2063 | 38 | 1.8

Contamination of midwives' hands

The second obstetrical clinic at Vienna General Hospital

Vienna General Hospital

The Vienna General Hospital is the University medical center of the city of Vienna, Austria. The AKH is the largest hospital of Austria and Europe, the second largest hospital in the world, and at 85-m high is one of the tallest hospital buildings in the world...

 that instructed midwife student evidently had a lower mortality rate than the first obstetrical clinic, where physicians were instructed.

While the midwife students in Vienna were not partaking in autopsies, there were still opportunities for them to contaminate their hands. In a lecture in 1846 Jakob Kolletschka

Jakob Kolletschka

Jakob Kolletschka was Professor of Forensic Medicine at Vienna General Hospital in Austria....

 is reputed to have said, "It is here no uncommon thing for midwives, especially in the commencement of their practice, to pull off legs and arms of infants, and even to pull away the entire body and leave the head in the uterus. Such occurrences are not altogether uncommon; they often happen.".

The Maternité in Paris was an exception. It was exclusively for the education of midwives, but it had a mortality rate as great as Paul-Antoine Dubois's Paris Clinic for the education of physicians. In the Maternité, midwives participated in autopsies as frequently physicians would elsewhere.

The hospital midwives and some of their students accompanied the physician on his daily rounds through the infirmary for maternity patients. Each student was assigned a diseased patient for particular observation and was expected to prepare a short case history of the birth and of the physician's treatment. Autopsies were conducted in a building in the garden somewhat removed from the maternity hospital; these were usually attended by student midwives. I was often astonished to see the active part some of the young women took in the dissection of corpses. With bare and bloody arms, holding large knives in their hands, laughing and quarreling, they cut the pelvis apart, having received permission from the physician to prepare the corpse for him.

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Ignaz Semmelweis

Ignaz Semmelweis

Ignaz Philipp Semmelweis was a Hungarian physician now known as an early pioneer of antiseptic procedures. Described as the "savior of mothers", Semmelweis discovered that the incidence of puerperal fever could be drastically cut by the use of hand disinfection in obstetrical clinics...

' Open Letter to all professors of obstetrics (1862) presents statistics from other European maternity institutions. The 1862 open letter is available at Austrian literature online, Österreichische Nationalbibliothek http://www.literature.at/webinterface/library/ALO-BOOK_V01?objid=13184 (in German, Gothic print)

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