Arts and entertainment

• Hot Spot (musical)
  Hot Spot (musical)
  Hot Spot is a musical with the book by Jack Weinstock and Willie Gilbert, lyrics by Martin Charnin, music by Mary Rodgers, and additional lyrics and music by Stephen Sondheim. It had a brief run on Broadway in 1963...
  
  , a 1963 Musical
• The Hot Spot
  The Hot Spot
  The Hot Spot is a 1990 American drama film directed by Dennis Hopper and based on the 1952 book Hell Hath No Fury by Charles Williams. It stars Don Johnson, Virginia Madsen, and Jennifer Connelly, and features a score by Jack Nitzsche played by John Lee Hooker, Miles Davis, Taj Mahal and Roy...
  
  , a 1990 film with Don Johnson and Jennifer Connelly
• Hot Spot (song)
  Hot Spot (song)
  "Hot Spot" is the first single released from American female hip-hop artist Foxy Brown's second album Chyna Doll. It was released in the United States on October 26, 1998. The single was produced by Murder Inc founder Irv Gotti and co-producer Lil' Rob, with lyrics written by Foxy Brown and...
  
  , by Foxy Brown
• Hot Spot (Transformers), the name of several Transformers characters
• Hot Spot (comics), a name for the DC Comics character Isaiah Crockett

Biology

• Biodiversity hotspot
  Biodiversity hotspot
  A biodiversity hotspot is a biogeographic region with a significant reservoir of biodiversity that is under threat from humans.The concept of biodiversity hotspots was originated by Norman Myers in two articles in “The Environmentalist” , revised after thorough analysis by Myers and others in...
  
  , a region of significant biodiversity
• Recombination hotspot
  Recombination hotspot
  Recombination hotspots are small regions in the genome of sexually reproducing organisms that exhibit highly elevated rates of meiotic recombination. The peak recombination rate within hotspots can be hundreds or thousands of times that of the surrounding region. The PRDM9 protein is suspected to...
  
  , a DNA position where genetic recombination occurs with above-average frequency
• Hot spot (veterinary medicine)
  Hot spot (veterinary medicine)
  In veterinary medicine, a "hot spot" is one of the many names for a raw, irritated lesion that results from a pet constantly scratching, chewing, and licking at an area of skin....
  
  

Computers

• Hot spot (computer science)
  Hot spot (computer science)
  A hot spot in computer science is most usually defined as a region of a computer program where a high proportion of executed instructions occur or where most time is spent during the program's execution .If a program is stopped randomly, the program counter...
  
  , region of a program where a significant amount of computation occurs
• Hot spot in a database
  Database
  A database is an organized collection of data for one or more purposes, usually in digital form. The data are typically organized to model relevant aspects of reality , in a way that supports processes requiring this information...
  
  , a database object which is frequently being accessed
• Hot spot, in software framework
  Software framework
  In computer programming, a software framework is an abstraction in which software providing generic functionality can be selectively changed by user code, thus providing application specific software...
  
  s, an area which is customized in various ways by users
• Hotspot (Wi-Fi)
  Hotspot (Wi-Fi)
  A hotspot is a site that offers Internet access over a wireless local area network through the use of a router connected to a link to an Internet service provider...
  
  , a Wi-Fi access point or area, in particular for connecting to the Internet
• HotSpot
  HotSpot
  HotSpot is a Java virtual machine for desktops and servers, maintained and distributed by Oracle Corporation. It features techniques such as just-in-time compilation and adaptive optimization designed to improve performance.-History:...
  
  , a Java Virtual Machine from Oracle
• Screen hotspot
  Screen hotspot
  A screen hotspot, in computing, provides a special area on the display screen of a computer for hyperlinking or for other GUI-based activity ....
  
  , especially in GUI applications, an area on which computer users click or hover for interactivity

Physics

• Hot spot (casting), a metal casting defect
• Hot spot effect in subatomic physics
  Hot spot effect in subatomic physics
  Hot spots in subatomic physics are regions of high energy density or temperature in hadronic or nuclear matter.-Finite size effects:Hot spots are a manifestation of the finite size of the system: in subatomic physics this refers both to atomic nuclei, which consist of nucleons, as well as to...
  
  , regions of high energy density or temperature in hadronic or nuclear matter

Other meanings

• Airport hot spots, locations where aircraft collisions with ground equipment may occur
• T-Mobile HotSpot, a service that allows mobile phone connections via a WiFi connection
• Hotspot Ecosystem Research and Man's Impact On European Seas
  Hotspot Ecosystem Research and Man's Impact On European Seas
  Hotspot Ecosystem Research and Man's Impact On European Seas, or HERMIONE, is an international multidisciplinary project, started in April 2009, that studies deep-sea ecosystems...
  
  , international research project