Hydrastine
Encyclopedia
Hydrastine is a natural alkaloid
which was discovered in 1851 by Alfred P. Durand. Hydrolysis of hydrastine yields hydrastinine
, which was patented by Bayer
as a haemostatic drug during the 1910s.
It is naturally present in Hydrastis canadensis
(thus the name) and other plants of the ranunculaceae
family.
Alkaloid
Alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids...
which was discovered in 1851 by Alfred P. Durand. Hydrolysis of hydrastine yields hydrastinine
Hydrastinine
Hydrastinine is a semisynthetic alkaloid from the hydrolysis of the alkaloid hydrastine, which was found naturally in small quantities in Hydrastis canadensis L. . Hydrastinine was produced by oxidative splitting of hydrastine hydrochloride with nitric acid in good yield...
, which was patented by Bayer
Bayer
Bayer AG is a chemical and pharmaceutical company founded in Barmen , Germany in 1863. It is headquartered in Leverkusen, North Rhine-Westphalia, Germany and well known for its original brand of aspirin.-History:...
as a haemostatic drug during the 1910s.
It is naturally present in Hydrastis canadensis
Goldenseal
Goldenseal is a perennial herb in the buttercup family Ranunculaceae, native to southeastern Canada and the northeastern United States. It may be distinguished by its thick, yellow knotted rootstock. The stem is purplish and hairy above ground and yellow below ground where it connects to the...
(thus the name) and other plants of the ranunculaceae
Ranunculaceae
Ranunculaceae are a family of about 1700 species of flowering plants in about 60 genera, distributed worldwide....
family.