IFL chemotherapy
Encyclopedia
IFL is a chemotherapy regimen for treatment of certain cancers, consisting of concurrent treatment with irinotecan
, leucovorin (folinic acid), and fluorouracil
.
It is similar to the FOLFIRI
regimen and uses the same drugs. However, the flurouracil component is given as a bolus injection rather than as an infusion over 48 hours.
Irinotecan
Irinotecan is a drug used for the treatment of cancer.Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin....
, leucovorin (folinic acid), and fluorouracil
Fluorouracil
Fluorouracil is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites...
.
It is similar to the FOLFIRI
FOLFIRI
FOLFIRI is a chemotherapy regimen for treatment of colorectal cancer. It is made up of the following drugs:* FOL – folinic acid , a vitamin B derivative used as a "rescue" drug for high doses of the drug methotrexate and that modulates/potentiates/reduces the side effects of fluorouracil;* F – ...
regimen and uses the same drugs. However, the flurouracil component is given as a bolus injection rather than as an infusion over 48 hours.