IRAK-4
Encyclopedia
IRAK-4 in the IRAK family, is a protein kinase
involved in signaling innate immune responses from Toll-like receptor
s. It also supports signaling from T-cell receptors.
Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS
challenge.
Protein kinase
A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them . Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins...
involved in signaling innate immune responses from Toll-like receptor
Toll-like receptor
Toll-like receptors are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes...
s. It also supports signaling from T-cell receptors.
Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS
Lipopolysaccharide
Lipopolysaccharides , also known as lipoglycans, are large molecules consisting of a lipid and a polysaccharide joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, act as endotoxins and elicit strong immune responses in animals.-Functions:LPS is the major...
challenge.