Indoprofen
Encyclopedia
Indoprofen is a non-steroidal anti-inflammatory drug
. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding
.
A 2004 study using high-throughput screening
found indoprofen to increase production of the survival of motor neuron
protein, suggesting it may provide insight into treatments for spinal muscular atrophies
.
Non-steroidal anti-inflammatory drug
Nonsteroidal anti-inflammatory drugs, usually abbreviated to NSAIDs or NAIDs, but also referred to as nonsteroidal anti-inflammatory agents/analgesics or nonsteroidal Anti-inflammatory medicines , are drugs with analgesic and antipyretic effects and which have, in higher doses, anti-inflammatory...
. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding
Gastrointestinal bleeding
Gastrointestinal bleeding or gastrointestinal hemorrhage describes every form of hemorrhage in the gastrointestinal tract, from the pharynx to the rectum. It has diverse causes, and a medical history, as well as physical examination, generally distinguishes between the main forms...
.
A 2004 study using high-throughput screening
High-throughput screening
High-throughput screening is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry. Using robotics, data processing and control software, liquid handling devices, and sensitive detectors, High-Throughput Screening allows a...
found indoprofen to increase production of the survival of motor neuron
Survival of motor neuron
The Survival of Motor Neuron is a protein involved in the assembly of snRNPs, the essential components of spliceosomal machinery. A lack of SMN due to SMN1 deletion results in widespread splicing defects, especially in spinal motor neurons, and is one cause of spinal muscular atrophy.SMN also...
protein, suggesting it may provide insight into treatments for spinal muscular atrophies
Spinal muscular atrophy
Spinal Muscular Atrophy is a neuromuscular disease characterized by degeneration of motor neurons, resulting in progressive muscular atrophy and weakness. The clinical spectrum of SMA ranges from early infant death to normal adult life with only mild weakness...
.