Indy, short for I'm not dead yet, is a gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

 of the model organism

Model organism

A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms. Model organisms are in vivo models and are widely used to...

, the fruitfly Drosophila melanogaster

Drosophila melanogaster

Drosophila melanogaster is a species of Diptera, or the order of flies, in the family Drosophilidae. The species is known generally as the common fruit fly or vinegar fly. Starting from Charles W...

. Mutant versions of this gene doubles the fruitflies' average life span

Life expectancy

Life expectancy is the expected number of years of life remaining at a given age. It is denoted by ex, which means the average number of subsequent years of life for someone now aged x, according to a particular mortality experience...

 (this is subject to controversy). Its name originates from a repeated comic line in Monty Python and the Holy Grail

Monty Python and the Holy Grail

Monty Python and the Holy Grail is a 1974 British comedy film written and performed by the comedy group Monty Python , and directed by Gilliam and Jones...

In a Yale University School of Medicine study by lead author and Howard Hughes Medical Institute

Howard Hughes Medical Institute

Howard Hughes Medical Institute is a United States non-profit medical research organization based in Chevy Chase, Maryland. It was founded by the American businessman Howard Hughes in 1953. It is one of the largest private funding organizations for biological and medical research in the United...

 investigator Gerald Shulman, the George R. Cowgill Professor of Physiological Chemistry

Physiological chemistry

Physiological chemistry is the chemistry of the organs and tissues of the body and of the various physiological processes incident to life. Physiological chemistry is essentially the precursor to modern biochemistry. In the nineteenth century, physiological chemistry dealt primarily with...

, Medicine, and Cellular and Molecular Biology

Molecular biology

Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...

, reduced expression of this gene in Drosophila melanogaster

Drosophila melanogaster

Drosophila melanogaster is a species of Diptera, or the order of flies, in the family Drosophilidae. The species is known generally as the common fruit fly or vinegar fly. Starting from Charles W...

flies and C. elegans

Caenorhabditis elegans

Caenorhabditis elegans is a free-living, transparent nematode , about 1 mm in length, which lives in temperate soil environments. Research into the molecular and developmental biology of C. elegans was begun in 1974 by Sydney Brenner and it has since been used extensively as a model...

worms modeled the effects on obesity and diabetes of caloric reduction in primates such as humans.

External links

• Indy at FlyBase
  FlyBase
  FlyBase is an online bioinformatics database and the primary repository of genetic and molecular data for the insect family Drosophilidae. For the most extensively studied species and model organism, Drosophila melanogaster, a wide range of data are presented in different formats...
  
  database of Drosophila genes.