The Influenza Research Database (IRD) is an integrative and comprehensive publicly-available database and analysis resource to search, analyze, visualize, save and share data for influenza virus research. IRD is one of the five Bioinformatics Resource Centers

Bioinformatics Resource Centers

The Bioinformatics Resource Centers are a group of five Internet-based research centers established in 2004 and funded by NIAID The BRCs were formed in response to the threats posed by emerging and re-emerging pathogens, particularly CDC Category A, B, and C pathogens, and their potential use in...

 (BRC) funded by the National Institute of Allergy and Infectious Diseases

National Institute of Allergy and Infectious Diseases

The National Institute of Allergy and Infectious Diseases is one of the 27 institutes and centers that make up the National Institutes of Health , an agency of the United States Department of Health and Human Services...

 (NIAID), a component of the National Institutes of Health

National Institutes of Health

The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...

 (NIH), which is an agency of the United States Department of Health and Human Services

United States Department of Health and Human Services

The United States Department of Health and Human Services is a Cabinet department of the United States government with the goal of protecting the health of all Americans and providing essential human services. Its motto is "Improving the health, safety, and well-being of America"...

.

Data types in IRD

• Segment, protein
  Protein
  Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
  
  , and strain data
• Animal surveillance data
• Human clinical data
• Immune epitopes
• Sequence Features
• 3D protein structures
• Experiment data
• PCR primer data
• Computationally-derived data

Analysis and visualization tools in IRD

• BLAST sequence similarity search
• Multiple sequence alignment
  Multiple sequence alignment
  A multiple sequence alignment is a sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. In many cases, the input set of query sequences are assumed to have an evolutionary relationship by which they share a lineage and are descended from a common ancestor...
  
  
• Phylogenetic tree
  Phylogenetic tree
  A phylogenetic tree or evolutionary tree is a branching diagram or "tree" showing the inferred evolutionary relationships among various biological species or other entities based upon similarities and differences in their physical and/or genetic characteristics...
  
   construction
• 3D protein structures with Sequence Feature or epitope highlights
• Sequence Feature Variant Type
  Sequence feature variant type
  The Sequence Feature Variant Type refers to the defined mutation of a given sequence feature in a protein. Consider a protein, its amino acid sequence determines the its structure and function...
  
  (SFVT) analysis
• Metadata-driven comparative analysis
• SNP analysis
• Sequence annotation
• Personal Workbench to save and share data and analysis

External links

• Bioinformatics Resource Centers The NIAID page describing the goals and activities of the BRCs