Integrin-linked kinase is a 59kDa protein originally identified while conducting a yeast-two hybrid screen with integrin β1 as the bait protein (Hannigan et al., 1996). Since its discovery, ILK has been associated with multiple cellular functions including cell migration, cell proliferation, cell-adhesions, signal transduction
In 2008, ILK was found to localize to the centrosome

Centrosome

In cell biology, the centrosome is an organelle that serves as the main microtubule organizing center of the animal cell as well as a regulator of cell-cycle progression. It was discovered by Edouard Van Beneden in 1883...

 and regulate mitotic spindle

Mitotic spindle

In cell biology, the spindle fibers are the structure that separates the chromosomes into the daughter cells during cell division. It is part of the cytoskeleton in eukaryotic cells...

 organization.

Interactions

Integrin-linked kinase has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with LIMS1

LIMS1

LIM and senescent cell antigen-like-containing domain protein 1 is a protein that in humans is encoded by the LIMS1 gene.-Interactions:LIMS1 has been shown to interact with Integrin-linked kinase and NCK2.-Further reading:...

, AKT1

AKT1

RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. Multiple alternatively spliced transcript variants have been found for this gene.- Function :...

, ILKAP

ILKAP

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.-Interactions:ILKAP has been shown to interact with Integrin-linked kinase.-Further reading:...

 and ACP6

ACP6

Lysophosphatidic acid phosphatase type 6 is an enzyme that in humans is encoded by the ACP6 gene.-Interactions:ACP6 has been shown to interact with Integrin-linked kinase.-Further reading:...

.

Further reading