Interferon gamma receptor 2
Encyclopedia
Interferon gamma receptor 2 also known as IFNGR2 is a protein
which in humans is encoded by the IFNGR2 gene
.
. Human interferon-gamma receptor is a heterodimer of IFNGR1
and IFNGR2.
disease (MSMD), also known as familial disseminated atypical mycobacterial infection.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
which in humans is encoded by the IFNGR2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptorInterferon-gamma receptor
The interferon-gamma receptor is a receptor which binds interferon-γ, the sole member of interferon type II.- Structure and function :...
. Human interferon-gamma receptor is a heterodimer of IFNGR1
Interferon gamma receptor 1
Interferon gamma receptor 1 also known as CD119 , is a human gene.- Function :...
and IFNGR2.
Clinical significance
Defects in IFNGR2 are a cause of autosomal recessive mendelian susceptibility to mycobacterialMycobacterium
Mycobacterium is a genus of Actinobacteria, given its own family, the Mycobacteriaceae. The genus includes pathogens known to cause serious diseases in mammals, including tuberculosis and leprosy...
disease (MSMD), also known as familial disseminated atypical mycobacterial infection.