Interleukin-1 receptor
Encyclopedia
Interleukin-1 receptor (IL-1R) is a cytokine receptor
which binds interleukin 1. Two forms of the receptor exist. The type I
receptor is primarily responsible for transmitting the inflammatory
effects of interleukin-1 (IL-1) while type II
receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding. Also opposing the effects of IL-1 is the IL-1 receptor antagonist
(IL-1RA).
The IL-1 receptor accessory protein (IL1RAP
) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.
Cytokine receptor
Cytokine receptors are receptors that bind cytokines.In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been...
which binds interleukin 1. Two forms of the receptor exist. The type I
Interleukin 1 receptor, type I
Interleukin 1 receptor, type I also known as CD121a , is an interleukin receptor. IL1R1 also denotes its human gene.-Interactions:...
receptor is primarily responsible for transmitting the inflammatory
Inflammation
Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process...
effects of interleukin-1 (IL-1) while type II
Interleukin 1 receptor, type II
Interleukin 1 receptor, type II also known as CD121b is an interleukin receptor. IL1R2 also denotes its human gene.-External links:...
receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding. Also opposing the effects of IL-1 is the IL-1 receptor antagonist
Interleukin 1 receptor antagonist
The interleukin-1 receptor antagonist is a protein that in humans is encoded by the IL1RN gene.IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA, is an agent that binds non-productively to the cell surface interleukin-1...
(IL-1RA).
The IL-1 receptor accessory protein (IL1RAP
IL1RAP
Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.-Interactions:IL1RAP has been shown to interact with TOLLIP and Interleukin 1 receptor, type I.-Further reading:...
) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.