Interleukin-27 receptor
Encyclopedia
The interleukin-27 receptor is a type I cytokine receptor
for interleukin-27. It is a heterodimer
composed of the interleukin 27 receptor, alpha subunit
and glycoprotein 130
.
IL27RA essential for transcriptional activation of STAT1
and for augmenting the induction of T-bet
expression during initiation of Th1 cell
differentiation.
Type I cytokine receptor
Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif in the extracellular portion...
for interleukin-27. It is a heterodimer
Protein dimer
In biochemistry, a dimer is a macromolecular complex formed by two, usually non-covalently bound, macromolecules like proteins or nucleic acids...
composed of the interleukin 27 receptor, alpha subunit
Interleukin 27 receptor, alpha subunit
Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.-Interactions:Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.-Further reading:...
and glycoprotein 130
Glycoprotein 130
Glycoprotein 130 is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family...
.
IL27RA essential for transcriptional activation of STAT1
STAT1
STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II or type III interferons...
and for augmenting the induction of T-bet
TBX21
T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene....
expression during initiation of Th1 cell
T helper cell
T helper cells are a sub-group of lymphocytes, a type of white blood cell, that play an important role in the immune system, particularly in the adaptive immune system. These cells have no cytotoxic or phagocytic activity; they cannot kill infected host cells or pathogens. Rather, they help other...
differentiation.