People

• Isaac Smith (Royal Navy officer) (1752–1831), Royal Navy officer and the first European to set foot in eastern Australia
• Isaac Smith (New Jersey)
  Isaac Smith (New Jersey)
  Isaac Smith was a United States Representative from New Jersey. Born in Trenton, he graduated from Princeton College in 1755, was a teacher in that institution from 1755 to 1758, studied medicine, and commenced practice in Trenton...
  
   (1740–1807), United States Representative from New Jersey
• Isaac Smith (Pennsylvania)
  Isaac Smith (Pennsylvania)
  Isaac Smith was a United States Representative from Pennsylvania.Irwin was born in Chester County, Pennsylvania. He engaged in agricultural pursuits near Level Corners, Pennsylvania. He was a member of the Pennsylvania House of Representatives from 1806 to 1808.Smith was elected as a Republican...
  
   (1761–1834), United States Representative from Pennsylvania
• Isaac E. Smith
  Isaac E. Smith
  Isaac Edgar Smith was a boat builder based in Port Washington, New York. Isaac, or "Ike" as he was commonly known, was born in Charleston, Illinois to Stephen Baldwin Smith and Mary Elizabeth Smith . His parents were residents of Port Washington, but had traveled to Illinois in 1856, returning to...
  
   (1858–1940), boat builder who built the first Star Class sailboats
• Isaac W. Smith (California politician)
• Isaac W. Smith (New Hampshire politician)
• Isaac W. Smith (surveyor)
  Isaac W. Smith (surveyor)
  Isaac Williams Smith was an American soldier, surveyor and engineer.-Early life:Smith was born in 1826 in Fredericksburg, Spotsylvania County, Virginia, the son of Episcopalian preacher Reverend George A...
  
   (1826–1897), American soldier and surveyor
• Isaac Smith (footballer)
  Isaac Smith (footballer)
  Isaac Smith is an Australian rules footballer who currently plays for Hawthorn in the Australian Football League ....
  
   (born 1988), Australian rules footballer

Vessels

• USS Isaac Smith (1851)
  USS Isaac Smith (1851)
  USS Isaac Smith was a steamer acquired by the Union Navy during the American Civil War. She was used by the Navy to patrol navigable waterways of the Confederacy to prevent the South from trading with other countries...
  
  , a Union Navy steamer in the American Civil War