Isovaleramide
Encyclopedia
Isovaleramide is an amide
found in Valerian root. In humans, it acts as a mild anxiolytic
at lower doses and as a mild sedative
at higher dosages. Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver
alcohol dehydrogenase
s and has a reported of greater than 400 mg/kg when administered intraperitoneally
in mice.
Amide
In chemistry, an amide is an organic compound that contains the functional group consisting of a carbonyl group linked to a nitrogen atom . The term refers both to a class of compounds and a functional group within those compounds. The term amide also refers to deprotonated form of ammonia or an...
found in Valerian root. In humans, it acts as a mild anxiolytic
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...
at lower doses and as a mild sedative
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....
at higher dosages. Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver
Liver
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion...
alcohol dehydrogenase
Alcohol dehydrogenase
Alcohol dehydrogenases are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide...
s and has a reported of greater than 400 mg/kg when administered intraperitoneally
Peritoneum
The peritoneum is the serous membrane that forms the lining of the abdominal cavity or the coelom — it covers most of the intra-abdominal organs — in amniotes and some invertebrates...
in mice.