Itraconazole , invented in 1984, is a triazole

Triazole

Triazole refers to either one of a pair of isomeric chemical compounds with molecular formula C2H3N3, having a five-membered ring of two carbon atoms and three nitrogen atoms.The two isomers are:*1,2,3-Triazole 100px*1,2,4-Triazole 100px...

 antifungal agent that is prescribed to patients with fungal infections. The drug may be given orally or intravenously.
Itraconazole has a broanst Aspergillus, which fluconazole is not. It is also licenced for use in blastomycosis

Blastomycosis

Blastomycosis is a fungal infection caused by the organism Blastomyces dermatitidis...

, histoplasmosis

Histoplasmosis

Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum. Symptoms of this infection vary greatly, but the disease primarily affects the lungs...

 and onychomycosis

Onychomycosis

Onychomycosis means fungal infection of the nail. It is the most common disease of the nails and constitutes about a half of all nail abnormalities....

. Itraconazole is over 99% protein bound and has virtually no penetration into cerebrospinal fluid

Cerebrospinal fluid

Cerebrospinal fluid , Liquor cerebrospinalis, is a clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord...

. Therefore, it should never be used to treat meningitis

Meningitis

Meningitis is inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation may be caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs...

 or other central nervous system

Central nervous system

The central nervous system is the part of the nervous system that integrates the information that it receives from, and coordinates the activity of, all parts of the bodies of bilaterian animals—that is, all multicellular animals except sponges and radially symmetric animals such as jellyfish...

 infections.