Ivar Karl Ugi
Encyclopedia
Ivar Karl Ugi was a German chemist
who made major contributions to organic chemistry
. He is known for the research on multicomponent reactions, yielding the Ugi reaction
.
. He did his habilitation 1960 at the same university. After a short but very successful career in industry at Bayer
from 1962 until 1968 when he joined the University of Southern California
at Los Angeles.
From 1971 he worked at the Technical University of Munich
, and was an emeritus from 1999 until his death in 2005.
or aldehyde
, an amine
, an isocyanide
and a carboxylic acid
to form a bis-amide
is generally known as Ugi reaction
.
Chemist
A chemist is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties such as density and acidity. Chemists carefully describe the properties they study in terms of quantities, with detail on the level of molecules and their component atoms...
who made major contributions to organic chemistry
Organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions, and preparation of carbon-based compounds, hydrocarbons, and their derivatives...
. He is known for the research on multicomponent reactions, yielding the Ugi reaction
Ugi reaction
The Ugi reaction is a multi-component reaction in organic chemistry involving a ketone or aldehyde, an amine, an isocyanide and a carboxylic acid to form a bis-amide.The reaction is named after Ivar Karl Ugi, who first published this reaction in 1959....
.
Biography
After he went to Germany from Estonia in 1941 he began his studies of chemistry in 1949 at the University of Tübingen until 1951. He became Dr. rer. nat. in 1954 at the Ludwig Maximilians University of MunichLudwig Maximilians University of Munich
The Ludwig Maximilian University of Munich , commonly known as the University of Munich or LMU, is a university in Munich, Germany...
. He did his habilitation 1960 at the same university. After a short but very successful career in industry at Bayer
Bayer
Bayer AG is a chemical and pharmaceutical company founded in Barmen , Germany in 1863. It is headquartered in Leverkusen, North Rhine-Westphalia, Germany and well known for its original brand of aspirin.-History:...
from 1962 until 1968 when he joined the University of Southern California
University of Southern California
The University of Southern California is a private, not-for-profit, nonsectarian, research university located in Los Angeles, California, United States. USC was founded in 1880, making it California's oldest private research university...
at Los Angeles.
From 1971 he worked at the Technical University of Munich
Technical University of Munich
The Technische Universität München is a research university with campuses in Munich, Garching, and Weihenstephan...
, and was an emeritus from 1999 until his death in 2005.
Research and development
The one pot reaction of a ketoneKetone
In organic chemistry, a ketone is an organic compound with the structure RCR', where R and R' can be a variety of atoms and groups of atoms. It features a carbonyl group bonded to two other carbon atoms. Many ketones are known and many are of great importance in industry and in biology...
or aldehyde
Aldehyde
An aldehyde is an organic compound containing a formyl group. This functional group, with the structure R-CHO, consists of a carbonyl center bonded to hydrogen and an R group....
, an amine
Amine
Amines are organic compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are derivatives of ammonia, wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group. Important amines include amino acids, biogenic amines,...
, an isocyanide
Isocyanide
An isocyanide is an organic compound with the functional group -N≡C. It is the isomer of the related cyanide , hence the prefix iso....
and a carboxylic acid
Carboxylic acid
Carboxylic acids are organic acids characterized by the presence of at least one carboxyl group. The general formula of a carboxylic acid is R-COOH, where R is some monovalent functional group...
to form a bis-amide
Amide
In chemistry, an amide is an organic compound that contains the functional group consisting of a carbonyl group linked to a nitrogen atom . The term refers both to a class of compounds and a functional group within those compounds. The term amide also refers to deprotonated form of ammonia or an...
is generally known as Ugi reaction
Ugi reaction
The Ugi reaction is a multi-component reaction in organic chemistry involving a ketone or aldehyde, an amine, an isocyanide and a carboxylic acid to form a bis-amide.The reaction is named after Ivar Karl Ugi, who first published this reaction in 1959....
.