JWH-359
Encyclopedia
JWH-359 is a dibenzopyran "classical" cannabinoid drug, which is a potent and selective CB2 receptor agonist, with a Ki
of 13.0nM and selectivity of around 220x for CB2 over CB1
receptors. It is related to other dibenzopyran CB2 agonists such as JWH-133
and L-759,656
but with a chiral side chain which has made it useful in mapping the shape of the CB2 binding site. It was discovered by, and named after, Dr. John W. Huffman
.
Dissociation constant
In chemistry, biochemistry, and pharmacology, a dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into...
of 13.0nM and selectivity of around 220x for CB2 over CB1
Cannabinoid receptor type 1
The cannabinoid receptor type 1, often abbreviated to CB1, is a G protein-coupled cannabinoid receptor located in the brain. It is activated by endocannabinoid neurotransmitters including anandamide and by the compound THC, found in the psychoactive drug cannabis.-Expression:The CB1 receptor is...
receptors. It is related to other dibenzopyran CB2 agonists such as JWH-133
JWH-133
JWH-133 is a potent selective CB2 receptor agonist, with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors. It was discovered by, and named after, John W...
and L-759,656
L-759,656
L-759,656 is an analgesic drug which is a cannabinoid agonist. It is a highly selective agonist for the CB2 receptor, with selectivity of 414x for CB2 over CB1, although it is still not as selective as newer agents such as HU-308....
but with a chiral side chain which has made it useful in mapping the shape of the CB2 binding site. It was discovered by, and named after, Dr. John W. Huffman
John W. Huffman
John William Huffman is a professor emeritus of organic chemistry at Clemson University who first synthesised many novel cannabinoids, including JWH-007, JWH-015, JWH-018, JWH-019, JWH-030, JWH-051, JWH-073, JWH-081, JWH-122, JWH-133, JWH-147, JWH-171, JWH-182, JWH-203, JWH-210, JWH-250, JWH-307,...
.