Janeway lesion
Encyclopedia
Janeway lesions are non-tender
, small erythematous or haemorrhagic macular or nodular
lesions on the palms or soles
only a few millimeters in diameter that are pathognomonic
of infective endocarditis
. Pathologically, the lesion is described to be a microabscess
of the dermis
with marked necrosis
and inflammatory infiltrate not involving the epidermis. They are caused by septic emboli which deposit bacteria, forming microabscesses. Janeway lesions are distal, flat, ecchymotic
, and painless.
Osler's node
s and Janeway lesions are similar, but Osler's nodes present with tenderness and are of immunologic origin.
(1872–1917), an American professor
of medicine
with interests in cardiology
and infectious disease
.
Tenderness
Tenderness can mean:* a tendency to express warm, compassionate, or affectionate feelings* delicate or intimate physical contact* tenderness – pain or discomfort when an affected area is touched-Other:...
, small erythematous or haemorrhagic macular or nodular
Nodule (medicine)
For use of the term nodule in dermatology, see Nodule In medicine, a nodule refers to a relatively hard, roughly spherical abnormal structure....
lesions on the palms or soles
Sole (foot)
The sole is the bottom of the foot.In humans the sole of the foot is anatomically referred to as the plantar aspect. The equivalent surface in ungulates is the hoof.- Human sole :...
only a few millimeters in diameter that are pathognomonic
Pathognomonic
Pathognomonic is a term, often used in medicine, that means characteristic for a particular disease. A pathognomonic sign is a particular sign whose presence means that a particular disease is present beyond any doubt...
of infective endocarditis
Endocarditis
Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves the heart valves . Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, or even on intracardiac devices...
. Pathologically, the lesion is described to be a microabscess
Abscess
An abscess is a collection of pus that has accumulated in a cavity formed by the tissue in which the pus resides due to an infectious process or other foreign materials...
of the dermis
Dermis
The dermis is a layer of skin between the epidermis and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis...
with marked necrosis
Necrosis
Necrosis is the premature death of cells in living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular death...
and inflammatory infiltrate not involving the epidermis. They are caused by septic emboli which deposit bacteria, forming microabscesses. Janeway lesions are distal, flat, ecchymotic
Ecchymosis
An ecchymosis is the medical term for a subcutaneous purpura larger than 1 centimeter or a hematoma, commonly called a bruise. It can be located in the skin or in a mucous membrane.-Presentation:...
, and painless.
Osler's node
Osler's node
Osler's nodes are painful, red, raised lesions found on the hands and feet. They are associated with a number of conditions, including infective endocarditis, and are caused by immune complex deposition. They are named after Sir William Osler who described them in the early 20th century...
s and Janeway lesions are similar, but Osler's nodes present with tenderness and are of immunologic origin.
Eponym
They are named after Theodore Caldwell JanewayTheodore Caldwell Janeway
Theodore Caldwell Janeway was the first full-time professor of medicine at the Johns Hopkins University School of Medicine, recruited in 1914.-Early on:...
(1872–1917), an American professor
Professor
A professor is a scholarly teacher; the precise meaning of the term varies by country. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences; a teacher of high rank...
of medicine
Medicine
Medicine is the science and art of healing. It encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
with interests in cardiology
Cardiology
Cardiology is a medical specialty dealing with disorders of the heart . The field includes diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart disease and electrophysiology...
and infectious disease
Infectious disease
Infectious diseases, also known as communicable diseases, contagious diseases or transmissible diseases comprise clinically evident illness resulting from the infection, presence and growth of pathogenic biological agents in an individual host organism...
.
