Johan Paulsson
Encyclopedia
Johan Paulsson is a Swedish mathematician
and systems biologist
at Harvard Medical School
. He is a leading researcher in systems biology
and stochastic process
es, specializing in stochasticity in gene networks and plasmid reproduction.
, a small city in the Swedish
province of Värmland
. He studied at Uppsala University
, where he obtained a BSc in Mathematics in 1996, a Masters of Science in Molecular Biology in 1996, and a Ph.D. in Molecular Biology in 2000 on stochasticity in intracellular circuits, in particular in plasmid copy control, under the supervision of Profs. Mans Ehrenberg and Kurt Nordström. In 2000 he moved to Princeton University
, where he was a Lewis-Thomas Fellow in Biophysics, where he did the research for his paper "Summing up the noise in genetic networks", which received wide attention because it gave a firm theoretical footing to the budding field of genetic noise. In 2003 he joined the Dept. of Applied Mathematics and
Theoretical Physics at the University of Cambridge
and was tenured the following year. In 2005 he moved to the recently created Department of Systems Biology at Harvard University, where he focused on the development of experimental techniques for counting plasmids in single cells and on theoretical results on control of fluctuations in gene expression.
He is married with one child.
as well as theoretical work on the stochastic processes on gene expression and copy number control
and work on muti-level selection by using experimental evolution.
His most influential publication is the analysis of all previous noise data and interpretations in one unified framework, which later guided many experimental approaches.
His last results are on the effects of partition in phenotypic variability,
the details of the stochastic processes that underlie gene expression noise and the limitations of the usual experimental approaches
and the fundamental limits of feedback as a noise control mechanism.
Mathematician
A mathematician is a person whose primary area of study is the field of mathematics. Mathematicians are concerned with quantity, structure, space, and change....
and systems biologist
Systems biology
Systems biology is a term used to describe a number of trends in bioscience research, and a movement which draws on those trends. Proponents describe systems biology as a biology-based inter-disciplinary study field that focuses on complex interactions in biological systems, claiming that it uses...
at Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
. He is a leading researcher in systems biology
Systems biology
Systems biology is a term used to describe a number of trends in bioscience research, and a movement which draws on those trends. Proponents describe systems biology as a biology-based inter-disciplinary study field that focuses on complex interactions in biological systems, claiming that it uses...
and stochastic process
Stochastic process
In probability theory, a stochastic process , or sometimes random process, is the counterpart to a deterministic process...
es, specializing in stochasticity in gene networks and plasmid reproduction.
Biography
Johan Paulsson was born in 1973, in KristinehamnKristinehamn
Kristinehamn is a locality and the seat of Kristinehamn Municipality, Värmland County, Sweden with 17,836 inhabitants in 2005.- Geography :Kristinehamn is situated by the shores of lake Vänern...
, a small city in the Swedish
Sweden
Sweden , officially the Kingdom of Sweden , is a Nordic country on the Scandinavian Peninsula in Northern Europe. Sweden borders with Norway and Finland and is connected to Denmark by a bridge-tunnel across the Öresund....
province of Värmland
Värmland
' is a historical province or landskap in the west of middle Sweden. It borders Västergötland, Dalsland, Dalarna, Västmanland and Närke. It is also bounded by Norway in the west. Latin name versions are Vermelandia and Wermelandia. Although the province's land originally was Götaland, the...
. He studied at Uppsala University
Uppsala University
Uppsala University is a research university in Uppsala, Sweden, and is the oldest university in Scandinavia, founded in 1477. It consistently ranks among the best universities in Northern Europe in international rankings and is generally considered one of the most prestigious institutions of...
, where he obtained a BSc in Mathematics in 1996, a Masters of Science in Molecular Biology in 1996, and a Ph.D. in Molecular Biology in 2000 on stochasticity in intracellular circuits, in particular in plasmid copy control, under the supervision of Profs. Mans Ehrenberg and Kurt Nordström. In 2000 he moved to Princeton University
Princeton University
Princeton University is a private research university located in Princeton, New Jersey, United States. The school is one of the eight universities of the Ivy League, and is one of the nine Colonial Colleges founded before the American Revolution....
, where he was a Lewis-Thomas Fellow in Biophysics, where he did the research for his paper "Summing up the noise in genetic networks", which received wide attention because it gave a firm theoretical footing to the budding field of genetic noise. In 2003 he joined the Dept. of Applied Mathematics and
Theoretical Physics at the University of Cambridge
University of Cambridge
The University of Cambridge is a public research university located in Cambridge, United Kingdom. It is the second-oldest university in both the United Kingdom and the English-speaking world , and the seventh-oldest globally...
and was tenured the following year. In 2005 he moved to the recently created Department of Systems Biology at Harvard University, where he focused on the development of experimental techniques for counting plasmids in single cells and on theoretical results on control of fluctuations in gene expression.
He is married with one child.
Work
His lab focused on the development of experimental techniques for counting plasmids, to extend his previous work on the mathematical aspects of plasmid replicationas well as theoretical work on the stochastic processes on gene expression and copy number control
and work on muti-level selection by using experimental evolution.
His most influential publication is the analysis of all previous noise data and interpretations in one unified framework, which later guided many experimental approaches.
His last results are on the effects of partition in phenotypic variability,
the details of the stochastic processes that underlie gene expression noise and the limitations of the usual experimental approaches
and the fundamental limits of feedback as a noise control mechanism.