John Auer
Encyclopedia
John Auer was an American physiologist and pharmacologist. He was a graduate of Johns Hopkins University
Medical School (1902), and was son-in-law to physiologist Samuel James Meltzer
(1851–1920), whom he closely worked with at the Rockefeller Institute for Medical Research.
The eponymous Auer rods
are named after him, which are rod-shaped inclusions in the cytoplasm
of myeloblasts. These were described by Auer in a 21-year-old patient suffering from a nosebleed and a sore throat.
Auer gave the first account regarding the physiological occurrences associated with anaphylaxis
, which he researched in experiments on guinea pigs. He performed a number of studies with his father-in-law involving the correlation between bronchial asthma and foreign substances, and with Meltzer, he also investigated the effects of magnesium
on tetany
. The term "Auer's phenomena" is named for allergic inflammations caused by exposure to xylene
, which he first described in experimentation on laboratory rabbits.
He is credited with ventilation of the lungs with anaesthesia during open thorax
surgery. His technique of intra-tracheal intubation is used to give continuous respiration to patients without respiratory lung movement.
Johns Hopkins University
The Johns Hopkins University, commonly referred to as Johns Hopkins, JHU, or simply Hopkins, is a private research university based in Baltimore, Maryland, United States...
Medical School (1902), and was son-in-law to physiologist Samuel James Meltzer
Samuel James Meltzer
Samuel James Meltzer was an American physiologist, born in Russia. He was educated at Konigsberg, Prussia, studied philosophy at and medicine at the University of Berlin ; and in the following year he emigrated to the United States, where he practiced his profession in New York City, serving as...
(1851–1920), whom he closely worked with at the Rockefeller Institute for Medical Research.
The eponymous Auer rods
Auer rods
Auer rods can be seen in the leukemic blasts of acute myeloid leukemia. Auer rods are clumps of azurophilic granular material that form elongated needles seen in the cytoplasm of leukemic blasts...
are named after him, which are rod-shaped inclusions in the cytoplasm
Cytoplasm
The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...
of myeloblasts. These were described by Auer in a 21-year-old patient suffering from a nosebleed and a sore throat.
Auer gave the first account regarding the physiological occurrences associated with anaphylaxis
Anaphylaxis
Anaphylaxis is defined as "a serious allergic reaction that is rapid in onset and may cause death". It typically results in a number of symptoms including throat swelling, an itchy rash, and low blood pressure...
, which he researched in experiments on guinea pigs. He performed a number of studies with his father-in-law involving the correlation between bronchial asthma and foreign substances, and with Meltzer, he also investigated the effects of magnesium
Magnesium
Magnesium is a chemical element with the symbol Mg, atomic number 12, and common oxidation number +2. It is an alkaline earth metal and the eighth most abundant element in the Earth's crust and ninth in the known universe as a whole...
on tetany
Tetany
Tetany has two meanings, though both are related to the muscular system.* Tetany * Tetany The terms "tetany" and "tetanus" are distinct....
. The term "Auer's phenomena" is named for allergic inflammations caused by exposure to xylene
Xylene
Xylene encompasses three isomers of dimethylbenzene. The isomers are distinguished by the designations ortho- , meta- , and para- , which specify to which carbon atoms the two methyl groups are attached...
, which he first described in experimentation on laboratory rabbits.
He is credited with ventilation of the lungs with anaesthesia during open thorax
Thorax
The thorax is a division of an animal's body that lies between the head and the abdomen.-In tetrapods:...
surgery. His technique of intra-tracheal intubation is used to give continuous respiration to patients without respiratory lung movement.